Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.41 |
| ▸ | PRKDC | P78527 | 11/20 | 0.41 |
| ▸ | ABL1 | P00519 | 9/20 | 0.41 |
| ▸ | EGFR | P00533 | 8/20 | 0.41 |
| ▸ | HCK | P08631 | 8/20 | 0.41 |
| ▸ | SRC | P12931 | 8/20 | 0.41 |
| ▸ | MTOR | P42345 | 8/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.41 |
| ▸ | KDR | P35968 | 8/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.36 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19763994 | 0.84 | RET (1.00) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726543 | 0.81 | RET (0.80) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726969 | 0.79 | RET (0.77) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726637 | 0.78 | RET (0.76) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726987 | 0.76 | RET (0.71) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL728046 | 0.75 | RET (0.69) | RETPIK3CDABL1EGFRSRC | |
| SCHEMBL728202 | 0.75 | RET (0.69) | RETPIK3CDABL1EGFRSRC | |
| SCHEMBL726560 | 0.75 | RET (0.69) | RETABL1EGFRSRCMTOR | |
| SCHEMBL10098362 | 0.74 | RET (0.56) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726350 | 0.73 | RET (0.66) | RETABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |