Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566930 | 0.93 | ACHE (0.41) | ACHEJAK1ROCK2SCN9ASCN5A | |
| SCHEMBL10099169 | 0.84 | EGFR (0.39) | ACHESCN9ASCN5AKCNH2CHRM4 | |
| SCHEMBL566439 | 0.79 | JAK1 (0.43) | ACHEJAK1ROCK2SCN9ASCN5A | |
| SCHEMBL16477564 | 0.76 | NSD2 (0.47) | ACHEJAK1SCN9ASCN5AKCNH2 | |
| SCHEMBL22613451 | 0.75 | KAT2B (0.42) | JAK1ROCK2SCN9ASCN5AKCNH2 | |
| SCHEMBL22613453 | 0.75 | KAT2B (0.42) | JAK1ROCK2SCN9ASCN5AKCNH2 | |
| SCHEMBL566470 | 0.75 | SCN9A (0.37) | JAK1SCN9ASCN5AKCNH2JAK2 | |
| SCHEMBL565567 | 0.75 | SCN9A (0.37) | JAK1SCN9ASCN5AKCNH2JAK2 | |
| SCHEMBL10099187 | 0.74 | JAK1 (0.42) | JAK1ROCK2SCN9ASCN5AKCNH2 | |
| SCHEMBL14697195 | 0.74 | SCN9A (0.42) | JAK1ROCK2SCN9ASCN5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | JAK2, JAK1, JAK3 | ACHE 4673/4885JAK1 2/4885ROCK2 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.