Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566821 | 0.92 | JAK2 (0.43) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL565488 | 0.88 | JAK2 (0.40) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL565545 | 0.87 | JAK2 (0.51) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL10099292 | 0.87 | JAK2 (0.36) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL10099177 | 0.85 | JAK2 (0.47) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL565660 | 0.80 | JAK2 (0.42) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL565661 | 0.80 | JAK2 (0.42) | JAK2JAK3JAK1PIK3CDGPR119 | |
| SCHEMBL566638 | 0.78 | JAK2 (0.37) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL14708566 | 0.76 | JAK2 (0.48) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL567238 | 0.75 | DGAT1 (0.38) | JAK2JAK3JAK1PIK3CDTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | JAK2, JAK1, JAK3 | JAK2 1/4885JAK3 3/4885JAK1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.