Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 20/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 17/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 16/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.61 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.61 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29402396 | 0.96 | ADORA2B (0.64) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343066 | 0.96 | ADORA2B (0.64) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343039 | 0.93 | ADORA2B (0.61) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343065 | 0.92 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL29402274 | 0.92 | ADORA2B (0.60) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343062 | 0.91 | ADORA2B (0.66) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL29402658 | 0.91 | ADORA2B (0.59) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343067 | 0.91 | ADORA2B (0.59) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343014 | 0.91 | ADORA2B (0.56) | ADORA2BADORA2AADORA1ADORA3PLK4 | |
| SCHEMBL21343011 | 0.90 | ADORA2B (0.57) | ADORA2BADORA2AADORA1ADORA3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143249-B2 | Prodrugs of A2B adenosine receptor antagonists | GILEAD SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |