ADORA2B

Adenosine receptor A2b · P29275 · ADORA2B on Sugi Atlas →

187,663 patent compounds predicted against ADORA2B, 103,509 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL188552	0.50	13/20
Furafylline (SCHEMBL191214)	0.76	12/20
SCHEMBL60158	0.67	12/20
SCHEMBL44805	1.00	11/20
Caffeine (SCHEMBL165192)	0.96	11/20
SCHEMBL59949	0.72	11/20
Dimethazan (SCHEMBL49056)	0.68	11/20
SCHEMBL150604	0.49	11/20
Caffeine (SCHEMBL5671)	1.00	10/20
Etofylline (SCHEMBL149271)	1.00	10/20
1-Methylxanthine (SCHEMBL10996)	1.00	9/20
Proxyphylline (SCHEMBL35569)	0.67	9/20
(S)-Proxyphylline (SCHEMBL35570)	0.67	9/20
Doxofylline (SCHEMBL37963)	0.62	9/20
SCHEMBL150602	0.59	9/20
SCHEMBL48434	0.53	9/20
SCHEMBL101922	0.47	9/20
SCHEMBL8565	0.42	9/20
Theophylline Anhydrous (SCHEMBL4915)	0.96	8/20
Theophylline Anhydrous (SCHEMBL5037)	0.81	8/20

Clinical trials — most relevant to ADORA2B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Stress Testing and Cardiac Magnetic Resonance	PHASE4	COMPLETED
Effects of Caffeine on Reinforcement Learning in Healthy Adults Using PET/MRI	PHASE4	RECRUITING
MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine	PHASE4	COMPLETED
Azelastine Fluticasone Combination vs. Fluticasone	PHASE4	WITHDRAWN
Allopurinol in Schizophrenia: A Randomized Trial Administering Allopurinol vs Placebo as add-on Antipsychotics in Patients With Schizophrenia	PHASE4	COMPLETED
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Preventing Acute Kidney Injury (AKI) in Pediatric Patients	PHASE3	UNKNOWN
Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Heart Failure Requiring IV Therapy	PHASE3	COMPLETED
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function	PHASE3	COMPLETED
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function	PHASE3	COMPLETED
Allopurinol for Mania: A Randomized Trial Administering Allopurinol vs. Placebo as add-on to Mood Stabilizers and/or Antipsychotics in Patients in a Bipolar Manic Episode	PHASE3	COMPLETED
Clonidine Versus Adenosine to Treat Neuropathic Pain	PHASE2	COMPLETED
KW-6002 to Treat Parkinson's Disease	PHASE2	COMPLETED
The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo	PHASE2	UNKNOWN
Study to Evaluate Adenosine 2A Receptor Agonist (Regadenoson) in Patients Undergoing Lung Transplantation	PHASE1	UNKNOWN
The Impact of Genotype on Pharmacokinetics and Antiplatelet Effects of Ticagrelor in Healthy Chinese	PHASE1	COMPLETED
Regadenoson Infusion of Marginalized Donor Lungs in an EVLP System	EARLY_PHASE1	COMPLETED
Effects of Aminophylline on Renal Function and Urine Volume of AKI Patient	EARLY_PHASE1	UNKNOWN
Polymorphisms, Caffeine and Sleep Disorders	nan	COMPLETED
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia	nan	COMPLETED
Adenosine and A2A Receptors in Human Brown Adipose Tissue	nan	COMPLETED
Poor Sleep and Inflammation in HIV-Infected Adults	nan	COMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Genetic Causes of Panic Disorder	nan	COMPLETED
Determination of Coronarphysiological Parameters With the Method of Thermodillution	nan	COMPLETED
BIOmarkers and PLAtelet Function Assessment in Myocardial Ischemia and Non Obstructive Coronary Arteries Study	nan	RECRUITING
Caffeine Efficacy in ADCY5-related Dyskinesia	nan	UNKNOWN
Pilot Study on Caffeine Efficiency in ADCY5-related Dyskinesia	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Genetic Studies in Difficult to Treat Asthma: TENOR	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADORA2B binder may also engage these)

Protein	Name	Similarity
Q6W3F4	—	1.000	Q6W3F4 →
P29276	—	1.000	P29276 →
Q32ZE2	—	1.000	Q32ZE2 →
Q60614	—	1.000	Q60614 →
Q1LZD0	—	1.000	Q1LZD0 →
O13076	—	0.983	O13076 →
Q60613	—	0.981	Q60613 →
P11617	—	0.981	P11617 →
P25102	—	0.978	P25102 →
P46616	—	0.977	P46616 →
Q9Y5Y3	—	0.976	Q9Y5Y3 →
P30543	—	0.976	P30543 →
Q9MZV8	—	0.975	Q9MZV8 →
ADORA2A	Adenosine receptor A2a	0.974	landscape →
Q7TQP3	—	0.974	Q7TQP3 →
O02667	—	0.974	O02667 →
Q6TLI7	—	0.973	Q6TLI7 →
Q6A155	—	0.972	Q6A155 →
Q76MS7	—	0.971	Q76MS7 →
P17124	—	0.971	P17124 →
P56451	—	0.971	P56451 →
P47747	—	0.970	P47747 →
P60021	—	0.970	P60021 →
O77616	—	0.970	O77616 →
P56448	—	0.970	P56448 →
MC5R	Melanocortin receptor 5	0.969	landscape →
HRH2	Histamine H2 receptor	0.969	landscape →
P61752	—	0.969	P61752 →
P47936	—	0.969	P47936 →
P32244	—	0.969	P32244 →