Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 8/20 | 0.38 |
| ▸ | MERTK | Q12866 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10100659 | 0.92 | KCNN4 (0.40) | KCNN4LRRK2BRD4AXLMERTK | |
| SCHEMBL10100700 | 0.92 | KCNN4 (0.40) | KCNN4LRRK2BRD4AXLMERTK | |
| SCHEMBL10100624 | 0.92 | MAP4K3 (0.43) | KCNN4LRRK2BRD4AXLMAPK1 | |
| SCHEMBL10100800 | 0.90 | KCNN4 (0.39) | KCNN4LRRK2AXLMERTKMAPK1 | |
| SCHEMBL10100802 | 0.88 | JAK2 (0.44) | KCNN4AXLMERTKFGFR1FGFR2 | |
| SCHEMBL15214061 | 0.86 | LRRK2 (0.39) | KCNN4LRRK2AXLMERTKMAPK1 | |
| SCHEMBL10100801 | 0.85 | KCNN4 (0.42) | KCNN4BRD4 | |
| SCHEMBL12539052 | 0.84 | MAP4K3 (0.55) | FGFR1FGFR2FGFR3MAP4K3MET | |
| SCHEMBL2358505 | 0.84 | LRRK2 (0.42) | LRRK2MAPK1FGFR1FGFR2FGFR3 | |
| SCHEMBL10100705 | 0.83 | LRRK2 (0.41) | LRRK2AXLMERTKMAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518938-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165333-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165333-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, ABL1 | KCNN4 4066/4885LRRK2 856/4885BRD4 2170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.