Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101357 | 0.89 | PIK3CB (0.40) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101159 | 0.82 | PIK3CB (0.45) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101168 | 0.80 | PIK3CB (0.42) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101356 | 0.80 | PIK3CB (0.42) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101156 | 0.80 | PIK3CB (0.45) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101149 | 0.78 | ENTPD5 (0.47) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101354 | 0.76 | PIK3CB (0.39) | PIK3CBTRPV1MAPKAPK2PTPN2PTPN1 | |
| SCHEMBL10101343 | 0.74 | CYP3A4 (0.37) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 | |
| SCHEMBL10101165 | 0.74 | PIK3CB (0.39) | PIK3CBMAPKAPK2CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10101133 | 0.73 | PIK3CB (0.47) | PIK3CBTRPV1MAPKAPK2ENTPD5IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101605-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC. (CA) | 2012-01-24 | — | — | US | disclosed |
| WO-2011069118-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS INC. (CA) | 2011-06-09 | — | — | WO | disclosed |
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS INC. (CA) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPM1D, PTPRO, PPM1G | PIK3CB 98/4885TRPV1 3145/4885MAPKAPK2 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.