Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENTPD5 | O75356 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | SOD1 | P00441 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101343 | 0.87 | CYP3A4 (0.37) | ENTPD5PIK3CBCYP3A4USP2HSP90AA1 | |
| SCHEMBL10101133 | 0.81 | PIK3CB (0.47) | ENTPD5PIK3CBCYP3A4MAPKAPK2ALDH1A1 | |
| SCHEMBL10101163 | 0.80 | PIK3CB (0.44) | ENTPD5PIK3CBCYP3A4USP2MAPKAPK2 | |
| SCHEMBL10101153 | 0.78 | PIK3CB (0.42) | ENTPD5PIK3CBCYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL10101157 | 0.78 | PIK3CB (0.57) | ENTPD5PIK3CBCYP3A4USP2KDM4E | |
| SCHEMBL10101152 | 0.78 | PIK3CB (0.46) | ENTPD5PIK3CBCYP3A4MAPKAPK2ALDH1A1 | |
| SCHEMBL10101160 | 0.78 | PIK3CB (0.42) | ENTPD5PIK3CBSOD1CYP3A4USP2 | |
| SCHEMBL10101357 | 0.77 | PIK3CB (0.40) | ENTPD5PIK3CBCYP3A4USP2HSP90AA1 | |
| SCHEMBL12234042 | 0.77 | ENTPD5 (0.63) | ENTPD5PIK3CBSOD1NR1H2NR1H3 | |
| SCHEMBL12234038 | 0.77 | ENTPD5 (0.63) | ENTPD5PIK3CBSOD1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101605-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC. (CA) | 2012-01-24 | — | — | US | disclosed |
| US-8101605-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC. (CA) | 2012-01-24 | — | — | US | disclosed |
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS INC. (CA) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPM1D, PTPRO, PPM1G | ENTPD5 750/4885PIK3CB 98/4885SOD1 3012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.