⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214440 | 1.00 | — | — | |
| SCHEMBL891139 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL3429783 | 0.98 | FDPS (0.44) | — | |
| SCHEMBL4654415 | 0.98 | CYP2D6 (0.48) | — | |
| Hydrochloric Acid SCHEMBL5682887 | 0.98 | FDPS (0.44) | — | |
| Hydrochloric Acid SCHEMBL3429292 | 0.98 | FDPS (0.44) | — | |
| Hydrochloric Acid SCHEMBL9739532 | 0.96 | CYP2D6 (0.47) | — | |
| Piperazine SCHEMBL28112800 | 0.94 | FDPS (0.42) | — | |
| SCHEMBL1190914 | 0.93 | — | — | |
| SCHEMBL2908604 | 0.93 | FDPS (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051963-B1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORP (US) | 2012-05-16 | — | — | EP | claimed |
| US-7786306-B2 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | SCHERING CORPORATION (US) | 2010-08-31 | — | — | US | claimed |
| EP-2051963-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A]PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2009-04-29 | — | — | EP | claimed |
| US-20080051579-A1 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same | MERCK SHARP & DOHME LLC | 2008-02-28 | — | — | US | claimed |
| WO-2008021509-A1 | PROCESS FOR RESOLVING CHIRAL PIPERIDINE ALCOHOL AND PROCESS FOR SYNTHESIS OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES USING SAME | SCHERING CORPORATION (US) | 2008-02-21 | — | — | WO | claimed |
| US-RE50776-E1 | Inhibitors of cyclin-dependent kinases | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2026-02-03 | — | — | US | disclosed |
| WO-2025067540-A1 | PYRAZOLOTRIAZINE AND PYRAZOLOPYRIMIDINE DERIVATIVES, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | 中国科学院上海药物研究所 | 2025-04-03 | — | — | WO | disclosed |
| US-12098154-B2 | Inhibitors of cyclin-dependent kinases | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-09-24 | — | — | US | disclosed |
| CN-118480029-A | 2-Aminopyrimidine compound or salt thereof, and preparation method and application thereof | 励缔(杭州)医药科技有限公司 | 2024-08-13 | — | — | CN | disclosed |
| US-20240246995-A1 | PYRIMIDINONE DERIVATIVE AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USE | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2024-07-25 | — | — | US | disclosed |
| US-20240166693-A1 | METHODS AND COMPOUNDS FOR MODULATING MYOTONIC DYSTROPY 1 | Design Therapeutics, Inc. | 2024-05-23 | — | — | US | disclosed |
| US-11945822-B2 | Pyrazolo-triazine and/or pyrazolo-pxrimidine derivatives as selective inhibitor of cyclin dependent kinase | QURIENT CO., LTD. (KR) | 2024-04-02 | — | — | US | disclosed |
| US-20040209878-A1 | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION AND PHARMACOPEIA, INC. | 2004-10-21 | — | — | US | disclosed |
| CN-1146543-C | Serine protease inhibitor | ��˹��ŵ�� | 2004-04-21 | — | — | CN | disclosed |
| CN-1348444-A | Serine protease inhibitor | AKZO NOBEL NV (NL) | 2002-05-08 | — | — | CN | disclosed |
| EP-1123280-A1 | SERINE PROTEASE INHIBITOR | Akzo Nobel N.V. (NL) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024718-A1 | SERINE PROTEASE INHIBITOR | AKZO NOBEL N.V. (NL) | 2000-05-04 | — | — | WO | disclosed |
| US-5917034-A | Antithrombotic n-amidinopiperidine and benzamidine derivatives | PFIZER INC. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0858458-A1 | ANTITHROMBOTIC N-AMIDINOPIPERIDINE AND BENZAMIDINE DERIVATIVES | Pfizer Limited (GB) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997016444-A1 | ANTITHROMBOTIC N-AMIDINOPIPERIDINE AND BENZAMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 1997-05-09 | — | — | WO | disclosed |