FDPS

Farnesyl pyrophosphate synthase · P14324 · FDPS on Sugi Atlas →

102,449 patent compounds predicted against FDPS, 45,636 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Ibandronic Acid (SCHEMBL9183)	1.00	19/20
Pamidronic Acid (SCHEMBL18361)	1.00	19/20
SCHEMBL34146	0.45	19/20
Alendronic Acid (SCHEMBL3388)	0.96	18/20
Acetic Acid (SCHEMBL35016)	0.45	17/20
SCHEMBL51479	0.41	17/20
Alendronic Acid (SCHEMBL18898)	1.00	16/20
SCHEMBL34812	0.44	16/20
SCHEMBL34918	0.44	16/20
SCHEMBL34969	0.42	16/20
SCHEMBL29389	0.38	16/20
SCHEMBL34458	0.38	16/20
Bromide (SCHEMBL30788)	0.38	16/20
Carnosol (SCHEMBL42365)	1.00	15/20
Etidronic Acid (SCHEMBL41737)	0.47	15/20
Hydrochloric Acid (SCHEMBL36719)	0.41	15/20
Alendronic Acid (SCHEMBL3389)	0.68	14/20
Etidronic Acid (SCHEMBL18607)	0.50	14/20
SCHEMBL34601	0.38	14/20
SCHEMBL34495	0.38	14/20

Clinical trials — most relevant to FDPS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety and Efficacy of Lapaquistat Acetate Taken Alone and With Atorvastatin in Subjects With Primary Dyslipidemia	PHASE3	COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC)	PHASE2	COMPLETED
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma	PHASE1/PHASE2	RECRUITING
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
Neoadjuvant Zoledronate and Atorvastatin in Triple Negative Breast Cancer	PHASE2	COMPLETED
Fosmidomycin and Azithromycin for Acute Uncomplicated Plasmodium Falciparum Malaria (P. Malaria) in Adults	PHASE2	UNKNOWN
Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate	PHASE2	WITHDRAWN
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC	PHASE2	COMPLETED
A Phase II Study of TX Regimen as First-line Treatment for Asian Elderly Patients With Advanced Adenocarcinoma of Lung	PHASE2	COMPLETED
BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC	PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Prospective Phase II Randomized Trial of Postoperative Adjuvant Chemotherapy in Patients With High Risk Colon Cancer	PHASE2	UNKNOWN
Leflunomide or Combination of MEK Inhibitor and Hydroxychloroquine for Refractory Patients With RAS Mutations	PHASE2	RECRUITING
Docetaxel Versus Docetaxel Plus Cisplatin Versus Docetaxel Plus S-1 as Second-line Chemotherapy in Metastatic Gastric Cancer	PHASE2	UNKNOWN
Modelle 001, TS-inhibition in Colorectal Liver Metastases Comparing Arfolitixorin and Calciumfolinate	PHASE1/PHASE2	UNKNOWN
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
A Study to Assess the Transfer of Fospropofol and Its Active Metabolite, Propofol, to Breast Milk Following Administration of LUSEDRA to Lactating Women Undergoing a Needed Procedure	PHASE1	COMPLETED
Clinical Effects of New Approach on Patients With Non-alcoholic Steatohepatitis	EARLY_PHASE1	COMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
SPK Study in Afghanistan	nan	COMPLETED
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization	nan	COMPLETED
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study	nan	COMPLETED
Familial Partial Lipodystrophy Study	nan	COMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a FDPS binder may also engage these)

Protein	Name	Similarity
P08836	—	0.989	P08836 →
P05369	—	0.987	P05369 →
Q920E5	—	0.978	Q920E5 →
Q8WMY2	—	0.975	Q8WMY2 →
P49353	—	0.973	P49353 →
Q43315	—	0.966	Q43315 →
GLS2	Glutaminase liver isoform, mitochondrial	0.966	landscape →
Q6F596	—	0.964	Q6F596 →
P49351	—	0.962	P49351 →
Q09152	—	0.962	Q09152 →
Q14CH1	—	0.962	Q14CH1 →
P49352	—	0.962	P49352 →
Q148G5	—	0.961	Q148G5 →
O64905	—	0.960	O64905 →
A0A7D0AGU9	—	0.960	A0A7D0AGU9 →
Q5T2R2	—	0.960	Q5T2R2 →
Q9WTN0	—	0.958	Q9WTN0 →
Q03426	—	0.958	Q03426 →
P17256	—	0.957	P17256 →
Q9WU79	—	0.957	Q9WU79 →
P28492	—	0.957	P28492 →
E2QUI9	—	0.956	E2QUI9 →
F9WZD2	—	0.955	F9WZD2 →
O43272	—	0.955	O43272 →
Q9ER88	—	0.955	Q9ER88 →
GGPS1	Geranylgeranyl pyrophosphate synthase	0.955	landscape →
O54783	—	0.954	O54783 →
P13439	—	0.954	P13439 →
P84850	—	0.954	P84850 →
O95671	—	0.954	O95671 →