Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | PCNA | P12004 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101383 | 0.86 | PIK3CB (0.39) | PIK3CBALOX15ALOX12 | |
| SCHEMBL10101188 | 0.86 | FKBP1A (0.41) | KDM4EALDH1A1HPGDHSD17B10FKBP1A | |
| SCHEMBL10101153 | 0.77 | PIK3CB (0.42) | ALDH1A1PIK3CBALOX15ALOX12 | |
| SCHEMBL10101164 | 0.76 | PIK3CB (0.45) | ALDH1A1KMT2APIK3CBALOX15ALOX12 | |
| SCHEMBL10101361 | 0.76 | PIK3CB (0.40) | ALDH1A1PIK3CBALOX15ALOX12 | |
| SCHEMBL10101186 | 0.76 | PIK3CB (0.39) | KDM4EALDH1A1HPGDCASP1CASP7 | |
| SCHEMBL10101338 | 0.76 | PIK3CB (0.41) | ALDH1A1PIK3CBALOX15ALOX12 | |
| SCHEMBL10101126 | 0.76 | PIK3CB (0.39) | ALDH1A1KMT2AMEN1PIK3CBALOX15 | |
| SCHEMBL10101365 | 0.76 | PIK3CB (0.39) | ALDH1A1POLBPIK3CBALOX15ALOX12 | |
| SCHEMBL10101249 | 0.75 | PIK3CB (0.40) | ALDH1A1PIK3CBALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101605-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC. (CA) | 2012-01-24 | — | — | US | disclosed |
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS INC. (CA) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPM1D, PTPRO, PPM1G | KDM4E 2971/4885ALDH1A1 1441/4885HPGD 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.