SCHEMBL10101974

SCHEMBL10101974

CNc1nc(Nc2ccc(OC)cc2)c(C#N)c(C)c1/N=N/c1c(C#N)cnn1-c1ncccn1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.41
ALDH1A1 P00352 4/20 0.41
HPGD P15428 2/20 0.41
HSD17B10 Q99714 2/20 0.41
GAA P10253 1/20 0.41
HTT P42858 1/20 0.39
MAPT P10636 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MAPK1 P28482 1/20 0.38
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CDK1 P06493 1/20 0.36
KDR P35968 1/20 0.36
MAP2K1 Q02750 6/20 0.36
RXFP1 Q9HBX9 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
SHMT2 P34897 1/20 0.33
MERTK Q12866 1/20 0.33
RAF1 P04049 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10106460 0.92 KDM4E (0.35) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL10102001 0.92 CSNK2A1 (0.35) KDM4EALDH1A1HPGDMAPTMAPK1
SCHEMBL10102105 0.91 ALDH1A1 (0.38) ALDH1A1MEN1KMT2AMAP2K1RXFP1
SCHEMBL10102041 0.91 ALDH1A1 (0.38) ALDH1A1MEN1KMT2AMAP2K1RXFP1
SCHEMBL10101976 0.90 CDK4 (0.35) KDM4EALDH1A1HPGDHSD17B10HTT
SCHEMBL10102018 0.90 ALDH1A1 (0.31) ALDH1A1HPGDSMN1; SMN2
SCHEMBL10102014 0.89 MAPT (0.37) KDM4EALDH1A1HPGDHSD17B10MAPT
SCHEMBL10101989 0.89 HPGD (0.44) KDM4EALDH1A1HPGDHSD17B10GAA
SCHEMBL10102017 0.88 MAP2K1 (0.39) ALDH1A1HPGDHTTMAPTL3MBTL1
SCHEMBL10102013 0.87 KDM4E (0.42) KDM4EALDH1A1HPGDHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8206465-B2 Azo pigments, pigment dispersion, coloring composition, and ink for inkjet recording FUJIFILM CORPORATION (JP) 2012-06-26 US disclosed
US-8206465-B2 Azo pigments, pigment dispersion, coloring composition, and ink for inkjet recording FUJIFILM CORPORATION (JP) 2012-06-26 US disclosed
US-20110011306-A1 AZO PIGMENTS, PIGMENT DISPERSION, COLORING COMPOSITION, AND INK FOR INKJET RECORDING FUJIFILM CORPORATION (JP) 2011-01-20 US disclosed
US-20110011306-A1 AZO PIGMENTS, PIGMENT DISPERSION, COLORING COMPOSITION, AND INK FOR INKJET RECORDING FUJIFILM CORPORATION (JP) 2011-01-20 US disclosed