⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29554953 | 1.00 | — | — | |
| SCHEMBL1314122 | 0.97 | TDP1 (0.46) | — | |
| SCHEMBL28085644 | 0.90 | TDP1 (0.41) | — | |
| SCHEMBL27699049 | 0.86 | RAPGEF4 (0.40) | — | |
| SCHEMBL3845672 | 0.79 | — | — | |
| SCHEMBL30548753 | 0.79 | — | — | |
| SCHEMBL12648843 | 0.78 | ESRRA (0.40) | — | |
| SCHEMBL79908 | 0.77 | — | — | |
| SCHEMBL29438559 | 0.77 | — | — | |
| SCHEMBL29370268 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 457 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112424177-B | One-pot organic pseudo-catalytic C-H activation method for preparing vortioxetine and vortioxetine intermediate | VIO制药公司 | 2024-05-03 | — | — | CN | claimed |
| EP-3810582-B1 | A ONE-POT ORGANO-PSEUDOCATALYTIC C-H ACTIVATION APPROACH FOR THE PREPARATION OF VORTIOXETINE AND VORTIOXETINE INTERMEDIATE | VIO AG PHARMACEUTICALS S A (GR) | 2024-01-03 | — | — | EP | claimed |
| CN-111269205-B | Preparation method of C-aryl glycoside compound | 华侨大学 | 2023-05-26 | — | — | CN | claimed |
| CN-110590642-B | Electroluminescent material with indenone as electron acceptor and its application | 大连理工大学 | 2022-06-07 | — | — | CN | claimed |
| CN-111484503-B | Mikanolide derivative and preparation method and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2022-05-27 | — | — | CN | claimed |
| CN-111484503-A | Mikanolide derivative and preparation method and application thereof | 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) | 2020-08-04 | — | — | CN | claimed |
| CN-108191792-B | Preparation method of vortioxetine hydrobromide and intermediate thereof | 上海博志研新药物技术有限公司 | 2020-03-27 | — | — | CN | claimed |
| CN-110615783-A | Electroluminescent material with pyrazinoindenone as electron acceptor and application thereof | 大连理工大学 | 2019-12-27 | — | — | CN | claimed |
| CN-110590642-A | Electroluminescent material with indenone as electron acceptor and its application | 大连理工大学 | 2019-12-20 | — | — | CN | claimed |
| CN-110590679-A | Method for catalytic synthesis of 5-substituted barbituric acid derivative by rare earth chloride | 上海城建职业学院 | 2019-12-20 | — | — | CN | claimed |
| CN-105461656-A | Novel process for preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl] piperazine | BEIJING VENTUREPHARM BIOTECH CORP | 2016-04-06 | — | — | CN | claimed |
| CN-105348220-A | Synthetic method for vortioxetine hydrobromide | SHANDONG CHUANCHENG PHARMACEUTICAL CO LTD | 2016-02-24 | — | — | CN | claimed |
| US-9133144-B2 | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine | H. LUNDBECK A/S (DK) | 2015-09-15 | — | — | US | claimed |
| US-20140343287-A1 | Process for the Manufacture of 1-[2-(2,4-Dimethyl-Phenylsulfanyl)-Phenyl]-Piperazine | H. LUNDBECK A/S (DK) | 2014-11-20 | — | — | US | claimed |
| EP-2800746-A1 | PROCESS FOR THE MANUFACTURE OF 1-[2-(2,4-DIMETHYL-PHENYLSULFANYL)-PHENYL]-PIPERAZINE | H. Lundbeck A/S (DK) | 2014-11-12 | — | — | EP | claimed |
| CN-104011034-A | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine | LUNDBECK & CO AS H | 2014-08-27 | — | — | CN | claimed |
| WO-2013102573-A1 | PROCESS FOR THE MANUFACTURE OF 1-[2-(2,4-DIMETHYL-PHENYLSULFANYL)-PHENYL]-PIPERAZINE | H. LUNDBECK A/S (DK) | 2013-07-11 | — | — | WO | claimed |
| CN-101861325-A | In the chemical reaction that the aryl boric acid that use replaces through the ortho position carries out, carboxylic acid is carried out organic catalysis activatory method | UNIV ALBERTA | 2010-10-13 | — | — | CN | claimed |
| EP-1963344-A1 | ORGANOPHOSPHORIC DERIVATIVES USEFUL AS ANTI-PARASITIC AGENTS | UNIVERSITEIT GENT (BE) | 2008-09-03 | — | — | EP | claimed |
| WO-2007071453-A1 | ORGANOPHOSPHORIC DERIVATIVES USEFUL AS ANTI-PARASITIC AGENTS | UNIVERSITEIT GENT (BE) | 2007-06-28 | — | — | WO | claimed |