Sugi Predict

Sugi Predict / Targets / RAPGEF4

RAPGEF4

Rap guanine nucleotide exchange factor 4 · Q8WZA2 · RAPGEF4 on Sugi Atlas →

24,170 patent compounds predicted against RAPGEF4, 11,849 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL502929 SCHEMBL502929 1.00 20/20
SCHEMBL801391 SCHEMBL801391 0.79 20/20
SCHEMBL503577 SCHEMBL503577 0.72 18/20
SCHEMBL246412 SCHEMBL246412 0.63 16/20
SCHEMBL234943 SCHEMBL234943 0.53 15/20
SCHEMBL812880 SCHEMBL812880 0.50 13/20
SCHEMBL28951 SCHEMBL28951 0.59 12/20
SCHEMBL776364 SCHEMBL776364 0.55 11/20
SCHEMBL323096 SCHEMBL323096 0.52 8/20
SCHEMBL330754 SCHEMBL330754 0.52 7/20
SCHEMBL216889 SCHEMBL216889 0.39 7/20
SCHEMBL692221 SCHEMBL692221 0.58 6/20
SCHEMBL7608 SCHEMBL7608 0.50 6/20
SCHEMBL23788 SCHEMBL23788 0.50 6/20
SCHEMBL113366 SCHEMBL113366 0.50 6/20
SCHEMBL317299 SCHEMBL317299 0.50 6/20
Water Water (SCHEMBL458685) 0.48 6/20
Hydroxyamine Hydroxyamine (SCHEMBL259333) 0.47 6/20
SCHEMBL20310 SCHEMBL20310 0.46 6/20
SCHEMBL647284 SCHEMBL647284 0.46 6/20

Clinical trials — most relevant to RAPGEF4 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
The Phosphodiesterase 4 Inhibitor Roflumilast as an Adjunct to Antidepressants in Major Depressive Disorder Patients PHASE1/PHASE2WITHDRAWN
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47) PHASE1/PHASE2NOT_YET_RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia PHASE1/PHASE2COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt) PHASE1/PHASE2RECRUITING
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer EARLY_PHASE1COMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Thrombin Regulated Platelet Activation nanCOMPLETED
The Influence of Genetic Variations in ELAPOR1 or ELAPOR2 on Insulin Secretion and Glucose Regulation in Humans nanUNKNOWN
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Autophagy in Systemic Lupus Erythematosus nanUNKNOWN
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men nanRECRUITING
The Genetic Study of Primary Angle-Closure Glaucoma nanUNKNOWN
Genetic Characterization of Parkinson's Disease nanCOMPLETED
NCF Gene & TNFSF4 in SLE Patients nanUNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Biomarkers of CASH nanACTIVE_NOT_RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis nanNOT_YET_RECRUITING
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Immune Cell Response to Stimuli nanRECRUITING
Investigation of Asprosin a Novel Adipokine in Periodontitis nanCOMPLETED
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RAPGEF4 binder may also engage these)

ProteinNameSimilarity
Q9EQZ6 — 1.000 Q9EQZ6 →
Q9Z1C7 — 0.991 Q9Z1C7 →
Q62245 — 0.985 Q62245 →
Q07139 — 0.984 Q07139 →
O02697 — 0.984 O02697 →
DNAJC13 DnaJ homolog subfamily C member 13 0.984 landscape →
P26675 — 0.984 P26675 →
Q9H8V3 — 0.982 Q9H8V3 →
Q9Y4G8 — 0.982 Q9Y4G8 →
O54785 — 0.982 O54785 →
Q95JW3 — 0.982 Q95JW3 →
Q8CHG7 — 0.982 Q8CHG7 →
P34152 — 0.981 P34152 →
Q5ZJX5 — 0.981 Q5ZJX5 →
F1M386 — 0.981 F1M386 →
Q86X27 — 0.981 Q86X27 →
Q21029 — 0.981 Q21029 →
F1PBJ0 — 0.981 F1PBJ0 →
Q3U0D9 — 0.981 Q3U0D9 →
PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0.981 landscape →
PLK2 Serine/threonine-protein kinase PLK2 0.981 landscape →
PTK2 Focal adhesion kinase 1 0.981 landscape →
Q5R8B7 — 0.980 Q5R8B7 →
A2APV2 — 0.980 A2APV2 →
E1C656 — 0.980 E1C656 →
O35346 — 0.980 O35346 →
Q9JHG7 — 0.980 Q9JHG7 →
Q5R4L1 — 0.980 Q5R4L1 →
Q00944 — 0.980 Q00944 →
Q8TEU7 — 0.980 Q8TEU7 →