Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10104431 | 0.98 | KDM4E (0.43) | KDM4EALDH1A1POLBCRHR1ATM | |
| SCHEMBL10104470 | 0.95 | KDM4E (0.46) | KDM4EALDH1A1POLBCRHR1ATM | |
| SCHEMBL10104463 | 0.87 | NR1H2 (0.53) | KDM4EALDH1A1POLBATMTDP1 | |
| SCHEMBL10104450 | 0.86 | CYP2A13 (0.44) | CRHR1ATMTDP1MEN1KMT2A | |
| SCHEMBL10104480 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1POLBCRHR1ATM | |
| SCHEMBL10104533 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1POLBCRHR1ATM | |
| SCHEMBL10104436 | 0.82 | RORC (0.46) | KDM4EALDH1A1ATMTDP1MEN1 | |
| SCHEMBL10104479 | 0.82 | KDM4E (0.43) | KDM4EALDH1A1POLBCRHR1ATM | |
| SCHEMBL10104461 | 0.80 | S1PR1 (0.37) | KDM4EALDH1A1ATMTDP1MEN1 | |
| SCHEMBL10104455 | 0.80 | SCN9A (0.40) | KDM4EATMTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778929-B2 | Substituted heteroaryl inhibitors of B-RAF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-15 | — | — | US | disclosed |
| US-8653087-B2 | Pyrido [5, 4-D] pyrimidines as cell proliferation inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| US-20120094975-A1 | PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-19 | — | — | US | disclosed |
| US-20110312939-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312939-A1 | NEW CHEMICAL COMPOUNDS | CCNA1, CCNT1, MKI67 | KDM4E 2715/4885ALDH1A1 175/4885POLB 3682/4885 |
| US-20120094975-A1 | PYRIDO [5, 4-D] PYRIMIDINES AS CELL PROLIFERATION INHIBITORS | CCNT1, CCNA1, CCND1 | KDM4E 1224/4885ALDH1A1 860/4885POLB 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.