RORC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL174114	1.00	20/20
SCHEMBL174479	1.00	20/20
SCHEMBL174641	1.00	20/20
SCHEMBL175040	1.00	20/20
SCHEMBL175183	1.00	20/20
SCHEMBL174561	0.92	20/20
SCHEMBL175072	0.89	20/20
SCHEMBL175194	0.86	20/20
SCHEMBL174084	0.85	20/20
SCHEMBL174154	0.85	20/20
SCHEMBL175214	0.85	20/20
SCHEMBL174203	0.83	20/20
SCHEMBL174639	0.83	20/20
SCHEMBL175182	0.81	20/20
SCHEMBL167597	0.79	20/20
SCHEMBL174891	0.78	20/20
SCHEMBL174439	0.81	19/20
SCHEMBL168480	0.57	17/20
SCHEMBL174165	0.72	16/20
SCHEMBL17126	0.54	16/20

Clinical trials — most relevant to RORC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Observation on the Efficacy and Mechanism of SLIT With Dust Mite Allergen for PAR	PHASE2/PHASE3	UNKNOWN
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
Prednisolone Trial in Children Younger Than 4 Years	PHASE3	COMPLETED
Latency in Pulmonary Tuberculosis	PHASE3	COMPLETED
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment	PHASE2	UNKNOWN
Fibrates in Pediatric Cholestasis	PHASE2	COMPLETED
Mechanistic Study of Indigo Naturalis in Treating Psoriasis	PHASE2	COMPLETED
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis	PHASE2	ACTIVE_NOT_RECRUITING
First in Human Study of NVG-111 in Relapsed/Refractory ROR1+ Malignancies	PHASE1	UNKNOWN
Meclizine for Hepatocellular Carcinoma	PHASE1	COMPLETED
Can Gluten-free Diet Prevent the Destruction of Beta-cells During Remission?	EARLY_PHASE1	UNKNOWN
A Study of RD14-01 in Patients With Advanced Solid Tumors	EARLY_PHASE1	UNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis	nan	COMPLETED
Phenotypic and Functional Profile of Peripheral Blood Lymphomonocytes in Seborrheic Dermatitis.	nan	COMPLETED
Investigation of Tumor Microenvironment After CRPC Along With Before and After Neoadjuvant Therapy for Prostate Cancer	nan	UNKNOWN
Gene Expression in Chronic Venous Leg Ulcers	nan	UNKNOWN
Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients	nan	UNKNOWN
Effect of Liraglutide on Clock Genes	nan	UNKNOWN
Prevalence Of Vitamin A Deficiency In Critically Ill Children With Sepsis And Its Association With Clinical Outcomes	nan	COMPLETED
Involvement of Pollutants in Atopic Dermatitis and Psoriasis	nan	UNKNOWN
Immune Benefits From Mushroom Consumption	nan	COMPLETED
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation	nan	COMPLETED
Gut Microbiome Analysis in Organ Transplant Recipient	nan	NOT_YET_RECRUITING
Basal Instincts: Towards Better Understanding of Basal Cell Function in Chronic Rhinosinusitis With Nasal Polyps	nan	RECRUITING
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity	nan	COMPLETED
Effect of Different Therapeutic Strategies on Regulatory T Cells in Kidney Transplantation	nan	COMPLETED
The Role of Regulatory T Cell in Patients With Type 1 Diabetes Mellitus	nan	UNKNOWN
Role of Obeticholic Acid in the Patients of NAFLD With Raised ALT	nan	COMPLETED
Prospective Observational Study Evaluating the Safety and Efficacy of Immunomodulatory Therapies in Refractory Inflammatory and Autoimmune Diseases	nan	NOT_YET_RECRUITING
Inflammatory Bowel Diseases (IBD) Cannabis Registry	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a RORC binder may also engage these)

Protein	Name	Similarity
Q5RAP4	—	1.000	Q5RAP4 →
P51450	—	1.000	P51450 →
NR1H3	Oxysterols receptor LXR-alpha	0.996	landscape →
Q9XSB5	—	0.996	Q9XSB5 →
Q9XSW2	—	0.996	Q9XSW2 →
Q5E9B6	—	0.996	Q5E9B6 →
Q9TU15	—	0.995	Q9TU15 →
Q62685	—	0.995	Q62685 →
P51448	—	0.995	P51448 →
P50241	—	0.995	P50241 →
O13012	—	0.995	O13012 →
P12813	—	0.995	P12813 →
NR4A1	Nuclear receptor subfamily 4immunitygroup A member 1	0.994	landscape →
Q9W6M2	—	0.994	Q9W6M2 →
P57717	—	0.994	P57717 →
P57753	—	0.994	P57753 →
Q9IAL9	—	0.994	Q9IAL9 →
P57782	—	0.994	P57782 →
Q9W669	—	0.994	Q9W669 →
P50569	—	0.994	P50569 →
NR1H2	Oxysterols receptor LXR-beta	0.994	landscape →
P33242	—	0.993	P33242 →
Q9QXZ7	—	0.993	Q9QXZ7 →
Q9YHZ7	—	0.993	Q9YHZ7 →
P50242	—	0.993	P50242 →
O97716	—	0.993	O97716 →
F1QLY4	—	0.993	F1QLY4 →
P06211	—	0.993	P06211 →
Q9YH33	—	0.993	Q9YH33 →
THRA	Thyroid hormone receptor alpha	0.993	landscape →