Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792508 | 0.91 | TSHR (0.56) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL20342825 | 0.89 | TSHR (0.55) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL27801663 | 0.89 | TSHR (0.55) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL27321459 | 0.89 | TSHR (0.55) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL3632329 | 0.88 | TSHR (0.53) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL13236484 | 0.86 | TSHR (0.60) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL2879819 | 0.85 | TSHR (0.58) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL30381190 | 0.85 | TSHR (0.58) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL3961070 | 0.85 | TSHR (0.58) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL9203388 | 0.85 | TSHR (0.58) | TSHRSMN1; SMN2HSD17B10TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2325176-B1 | Process for the preparation of Isoxazolin-3-yl-Acylbenzenes | BASF SE (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2298749-B1 | Process for the preparation of Thioethers | BASF SE (DE) | 2014-12-24 | — | — | EP | disclosed |
| US-8124810-B2 | Preparation of isoxazolin-3-ylacylbenzenes | BASF SE (DE) | 2012-02-28 | — | — | US | disclosed |
| US-8049017-B2 | Preparation of isoxazolin-3-ylacylbenzenes | BASF SE (DE) | 2011-11-01 | — | — | US | disclosed |
| US-8049017-B2 | Preparation of isoxazolin-3-ylacylbenzenes | BASF SE (DE) | 2011-11-01 | — | — | US | disclosed |
| US-20110152535-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | RHEINHEIMER JOACHIM | 2011-06-23 | — | — | US | disclosed |
| US-20110152535-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | RHEINHEIMER JOACHIM | 2011-06-23 | — | — | US | disclosed |
| EP-2325176-A1 | Process for the preparation of isoxazolin-3-yl-acylbenzenes | BASF SE (DE) | 2011-05-25 | — | — | EP | disclosed |
| EP-2298749-A1 | Process for the preparation of Thioethers | BASF SE (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-20100105920-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | BASF SE (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100105920-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | BASF SE (DE) | 2010-04-29 | — | — | US | disclosed |
| US-7663001-B2 | Preparation of isoxazolin-3-ylacylbenzene | BASF AKTIENGESELLSCHAFT (DE) | 2010-02-16 | — | — | US | disclosed |
| US-7309802-B2 | Preparation of isoxazolin-3-ylacylbenzene | BASF AKTIENGESELLSCHAFT (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309802-B2 | Preparation of isoxazolin-3-ylacylbenzene | BASF AKTIENGESELLSCHAFT (DE) | 2007-12-18 | — | — | US | disclosed |
| EP-1852424-A2 | Method for manufacturing isoxazoline-3-yL-acyl benzoles | BASF AKTIENGESELLSCHAFT (DE) | 2007-11-07 | — | — | EP | disclosed |
| US-20070161800-A1 | Preparation of Isoxazolin-3-Ylacylbenzene | BASF SE (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161800-A1 | Preparation of Isoxazolin-3-Ylacylbenzene | BASF SE (DE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161800-A1 | Preparation of Isoxazolin-3-Ylacylbenzene | CBR3, UQCRB, CYP4X1 | TSHR 311/4885SMN1; SMN2 4342/4885HSD17B10 342/4885 |
| US-20110152535-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | CBR3, CYP4X1, UQCRB | TSHR 353/4885SMN1; SMN2 4343/4885HSD17B10 436/4885 |
| US-20100105920-A1 | PREPARATION OF ISOXAZOLIN-3-YLACYLBENZENES | CBR3, CYP4X1, UQCRB | TSHR 353/4885SMN1; SMN2 4343/4885HSD17B10 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.