Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549898 | 0.90 | HTR6 (0.67) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL2719797 | 0.90 | HTR6 (0.54) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9105971 | 0.89 | HTR6 (0.53) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL6185721 | 0.83 | HTR6 (0.66) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6189424 | 0.82 | HTR6 (0.64) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL4550066 | 0.81 | HTR6 (0.62) | HTR6HTR1AHTR2CHTR7HTR2B | |
| SCHEMBL9889154 | 0.80 | HTR6 (0.64) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2720926 | 0.80 | HTR6 (0.61) | HTR6HTR1AHTR2CHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL2720322 | 0.80 | HTR6 (0.63) | HTR6KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL6187692 | 0.77 | HTR6 (0.84) | HTR6KMT2AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059432-A1 | N-PHENYL-(HOMO)PIPERAZINYL-BENZENESULFONYL OR BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO THE MODULATION OF THE 5-HT6 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2012-05-10 | — | — | WO | disclosed |