HTR6

5-hydroxytryptamine receptor 6 · P50406 · HTR6 on Sugi Atlas →

332,692 patent compounds predicted against HTR6, 184,473 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL45741	0.63	15/20
SCHEMBL30898	1.00	14/20
SCHEMBL31403	1.00	14/20
Eletriptan (SCHEMBL26719)	0.67	12/20
Trazodone (SCHEMBL28167)	0.94	10/20
Trazodone (SCHEMBL61754)	0.92	10/20
SCHEMBL47984	0.37	9/20
SCHEMBL17803	0.46	8/20
(Phenylsulfonyl)Benzene (SCHEMBL30255)	1.00	7/20
SCHEMBL34558	0.77	7/20
SCHEMBL15444	0.74	7/20
SCHEMBL34500	0.67	7/20
Ergotamine (SCHEMBL1483)	1.00	6/20
Ergotamine (SCHEMBL8045)	0.93	6/20
Ergotamine (SCHEMBL8046)	0.93	6/20
Ergotamine (SCHEMBL42443)	0.85	6/20
SCHEMBL77148	0.59	6/20
SCHEMBL77738	0.47	6/20
Metralindole (SCHEMBL49688)	0.40	6/20
Mebhydrolin (SCHEMBL29802)	0.65	5/20

Clinical trials — most relevant to HTR6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Serotonergic Modulation of Cognition, Emotion and Brain Activation in Healthy Volunteers	PHASE4	COMPLETED
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects	PHASE1	COMPLETED
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis	EARLY_PHASE1	UNKNOWN
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Human Cerebral Blood Flow and Serotonin	nan	UNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis	nan	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients	nan	UNKNOWN
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
Psychobiological Characterization of Depression in Hepatitis C	nan	UNKNOWN
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED
A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.	nan	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Molecular Genetic Study of Schizophrenia: Parent-Offspring Trios	nan	COMPLETED
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome	nan	COMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a HTR6 binder may also engage these)

Protein	Name	Similarity
Q5IS65	—	1.000	Q5IS65 →
P31388	—	1.000	P31388 →
Q9R1C8	—	1.000	Q9R1C8 →
ADRB3	Beta-3 adrenergic receptor	0.996	landscape →
Q95252	—	0.995	Q95252 →
Q9XT58	—	0.993	Q9XT58 →
Q28524	—	0.991	Q28524 →
P51436	—	0.990	P51436 →
P30729	—	0.990	P30729 →
Q7TQN7	—	0.989	Q7TQN7 →
Q7TQP2	—	0.988	Q7TQP2 →
Q9XT57	—	0.988	Q9XT57 →
P46626	—	0.986	P46626 →
P25962	—	0.986	P25962 →
GALR2	Galanin receptor type 2	0.986	landscape →
O02662	—	0.984	O02662 →
Q9TST4	—	0.983	Q9TST4 →
P26255	—	0.982	P26255 →
Q60483	—	0.982	Q60483 →
O08726	—	0.981	O08726 →
RXFP4	Relaxin-3 receptor 2	0.979	landscape →
P97714	—	0.979	P97714 →
O70432	—	0.978	O70432 →
Q8IZ08	—	0.978	Q8IZ08 →
P34971	—	0.977	P34971 →
Q862A8	—	0.977	Q862A8 →
O88854	—	0.976	O88854 →
Q80T02	—	0.976	Q80T02 →
Q80SS6	—	0.976	Q80SS6 →
Q9TT96	—	0.976	Q9TT96 →