Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010089 | 0.88 | GAA (0.39) | HPGDLMNAEPHX1RAB9AEPHX2 | |
| SCHEMBL1011123 | 0.87 | GAA (0.38) | SMN1; SMN2LMNAEPHX1EPHX2GAA | |
| SCHEMBL2003191 | 0.85 | TBXA2R (0.43) | SMN1; SMN2HPGDLMNAEPHX1RAB9A | |
| SCHEMBL1010949 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDLMNAEPHX1RAB9A | |
| SCHEMBL1652427 | 0.80 | TBXA2R (0.40) | LMNAEPHX1RAB9AEPHX2NPC1 | |
| SCHEMBL5961320 | 0.79 | EPHX1 (0.41) | SMN1; SMN2HPGDLMNAEPHX1RAB9A | |
| SCHEMBL2005214 | 0.79 | PTGDR2 (0.43) | HPGDEPHX1RAB9ANPC1ALDH1A1 | |
| SCHEMBL8737850 | 0.79 | PTGDR2 (0.43) | SMN1; SMN2HPGDLMNAEPHX1RAB9A | |
| SCHEMBL1652114 | 0.78 | EPHX1 (0.42) | SMN1; SMN2EPHX1RAB9AEPHX2NPC1 | |
| SCHEMBL2007358 | 0.78 | PTGDR2 (0.51) | SMN1; SMN2HPGDLMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |