Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010686 | 0.88 | SMN1; SMN2 (0.39) | GAAEPHX1POLBALDH1A1KMT2A | |
| SCHEMBL1011123 | 0.87 | GAA (0.38) | GAAHDAC1HDAC6EPHX1POLB | |
| SCHEMBL3443109 | 0.84 | POLB (0.39) | GAAHDAC1HDAC6EPHX1POLB | |
| SCHEMBL12568979 | 0.81 | EPHX2 (0.38) | GAAHDAC1HDAC6EPHX1POLB | |
| SCHEMBL1011805 | 0.80 | COPS5 (0.36) | ALDH1A1KMT2ARAB9AMEN1LMNA | |
| SCHEMBL1009043 | 0.77 | COPS5 (0.40) | ALDH1A1KMT2ACYP3A4MEN1LMNA | |
| SCHEMBL6016869 | 0.77 | GAA (0.40) | GAAHDAC1HDAC6EPHX1POLB | |
| SCHEMBL8737850 | 0.76 | PTGDR2 (0.43) | GAAHDAC1HDAC6EPHX1POLB | |
| SCHEMBL8738226 | 0.73 | PTGDR2 (0.44) | GAAPOLBALDH1A1KMT2AHPGD | |
| SCHEMBL1924122 | 0.72 | TBXA2R (0.38) | ALDH1A1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |