SCHEMBL10107288

SCHEMBL10107288

O=C(OC1CCCO1)c1cc(C(F)(F)F)ccc1O[C@H]1C[C@H]2CC[C@@H](C1)N2c1ccc(C(F)(F)F)cn1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 7/20 0.38
KDM4E B2RXH2 1/20 0.37
ABL1 P00519 1/20 0.37
LMNA P02545 1/20 0.37
LIPG Q9Y5X9 2/20 0.37
TSHR P16473 1/20 0.36
HRH3 Q9Y5N1 3/20 0.35
SCN8A Q9UQD0 1/20 0.35
SCN10A Q9Y5Y9 1/20 0.35
HDAC11 Q96DB2 1/20 0.33
LPL P06858 1/20 0.33
SLC6A9 P48067 1/20 0.33
KCNH2 Q12809 1/20 0.33
SLC6A5 Q9Y345 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13799820 1.00 CNR2 (0.38) CNR2KDM4EABL1LMNALIPG
SCHEMBL16433645 0.94 KDM4E (0.39) CNR2KDM4EABL1LMNATSHR
SCHEMBL12962015 0.92 CNR2 (0.40) CNR2KDM4EABL1LMNALIPG
SCHEMBL13799819 0.84 LIPG (0.48) KDM4EABL1LMNALIPGHRH3
SCHEMBL10107285 0.84 LIPG (0.48) KDM4EABL1LMNALIPGHRH3
SCHEMBL10107306 0.83 KDM4E (0.43) KDM4EABL1LMNALIPGHRH3
SCHEMBL13799821 0.83 KDM4E (0.43) KDM4EABL1LMNALIPGHRH3
SCHEMBL13813306 0.82 CNR2 (0.40) CNR2KDM4EABL1LMNALIPG
SCHEMBL10107254 0.78 KDM4E (0.41) KDM4EABL1LMNALIPGHRH3
SCHEMBL13799813 0.78 KDM4E (0.41) KDM4EABL1LMNALIPGHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE45364-E1 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2015-02-03 US disclosed
US-8101768-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2012-01-24 US disclosed
US-8101768-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2012-01-24 US disclosed
US-7868178-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2011-01-11 US disclosed
US-7485727-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2009-02-03 US disclosed
US-7485727-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2009-02-03 US disclosed
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2008-12-25 US disclosed
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent NIPPON SODA CO., LTD. (JP) 2008-02-21 US disclosed
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent NIPPON SODA CO., LTD. (JP) 2008-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent H1-0, H1-2, H1-4 CNR2 1207/4885KDM4E 373/4885ABL1 876/4885
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT H1-0, H1-2, H1-4 CNR2 1312/4885KDM4E 339/4885ABL1 873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.