LIPG — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL133316	0.87	14/20
SCHEMBL90476	0.76	14/20
SCHEMBL171778	0.65	14/20
SCHEMBL28217	0.56	14/20
SCHEMBL203692	0.51	14/20
SCHEMBL120527	0.75	13/20
SCHEMBL104247	0.65	13/20
Hydrochloric Acid (SCHEMBL101098)	0.61	13/20
SCHEMBL70387	0.59	13/20
SCHEMBL102562	0.59	13/20
SCHEMBL171682	0.59	13/20
SCHEMBL87138	0.55	13/20
SCHEMBL121468	0.54	13/20
SCHEMBL47074	0.53	13/20
SCHEMBL59080	0.53	13/20
SCHEMBL101385	0.53	13/20
SCHEMBL103840	0.51	13/20
SCHEMBL189992	0.50	13/20
SCHEMBL10323	0.88	12/20
SCHEMBL64653	0.61	12/20

Clinical trials — most relevant to LIPG by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons	PHASE4	COMPLETED
Stem Cell Mobilization With Plerixafor in Diabetic vs Control Subjects	PHASE4	COMPLETED
Omacor for the Treatment of Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus	PHASE4	COMPLETED
The Effects of Dapagliflozin on HDL Particles Subtypes and Reverse Cholesterol Transport in Type 2 Diabetic Patients	PHASE4	COMPLETED
Acute Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon	PHASE4	COMPLETED
Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee	PHASE4	RECRUITING
Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function	PHASE4	COMPLETED
PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic Stroke	PHASE4	NOT_YET_RECRUITING
High-Density Lipoprotein (HDL) Modulation and Endothelial Function	PHASE3	COMPLETED
A Mechanistic Study of the Effects of LY518674 on High-Density Lipoprotein Cholesterol (HDL-C) Metabolism	PHASE2	COMPLETED
Assessment of Coronary Plaque Composition	PHASE1	COMPLETED
The Fasting Study - Unraveling the Mechanistic Effects of Prolonged Fasting in Humans.	nan	COMPLETED
Production of Free Fatty Acids From Blood Triglycerides	nan	COMPLETED
Relation of Antibodies Against Oxidized Low Density Lipoproteins to Disease Activity and Cardiovascular Affection in Systemic Lupus.	nan	UNKNOWN
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
Effectiveness of Nutritional Program Among Diabetic Patients	nan	UNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract	nan	UNKNOWN
Hypertriglyceridemia-associated Acute Pancreatitis: Apheresis Vs. Conservative Treatment	nan	COMPLETED
Association Between HDL Functions and Atherosclerotic Burden in Healthy Individuals	nan	COMPLETED
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome	nan	COMPLETED
Effect of Saturated Fat on Large Low-density Lipoprotein (LDL) and High-density Lipoprotein (HDL)	nan	COMPLETED
Free Fatty Acids-Induced Hypertension in Obese Subjects (Aim #2)	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Effect of Probiotic Supplementation on Endothelial Function II	nan	COMPLETED
Epidemiology of Atherosclerosis	nan	COMPLETED
Sleep Restriction and Postprandial Lipemia	nan	COMPLETED
Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.	nan	RECRUITING
Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.	nan	UNKNOWN
Health Improvements by Understanding the Determinants of Residual Risk in Coronary Artery Disease and New Targets for Prevention and Treatment	nan	RECRUITING
Short Interval Resveratrol Trial in Cardiovascular Surgery	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a LIPG binder may also engage these)

Protein	Name	Similarity
Q8VBX1	—	0.990	Q8VBX1 →
Q9WVG5	—	0.989	Q9WVG5 →
J3RZ81	—	0.981	J3RZ81 →
P11602	—	0.972	P11602 →
P49923	—	0.967	P49923 →
LPL	Lipoprotein lipase	0.965	landscape →
P55031	—	0.965	P55031 →
P07867	—	0.964	P07867 →
O46647	—	0.962	O46647 →
P11151	—	0.962	P11151 →
P49060	—	0.962	P49060 →
P11153	—	0.960	P11153 →
Q29524	—	0.960	Q29524 →
O46559	—	0.960	O46559 →
P27656	—	0.959	P27656 →
P97535	—	0.958	P97535 →
Q8VI78	—	0.956	Q8VI78 →
O35276	—	0.955	O35276 →
LIPC	Hepatic triacylglycerol lipase	0.955	landscape →
Q06000	—	0.955	Q06000 →
Q5E9H0	—	0.955	Q5E9H0 →
O35375	—	0.955	O35375 →
P11152	—	0.955	P11152 →
O60462	—	0.951	O60462 →
A8WCC4	—	0.950	A8WCC4 →
P07225	—	0.949	P07225 →
Q5RBQ5	—	0.949	Q5RBQ5 →
Q53H76	—	0.949	Q53H76 →
Q3SZ79	—	0.948	Q3SZ79 →
Q6NRQ1	—	0.948	Q6NRQ1 →