SCHEMBL1010757

SCHEMBL1010757

CN1C2CCC1CC(CC(O)(c1cccs1)c1cccs1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 19/20 1.00
CHRM2 P08172 11/20 0.62
CHRM1 P11229 11/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4162558 0.95 CHRM3 (0.90) CHRM3CHRM2CHRM1
SCHEMBL5432731 0.95 CHRM3 (0.90) CHRM3CHRM2CHRM1
SCHEMBL4162557 0.95 CHRM3 (0.90) CHRM3CHRM2CHRM1
SCHEMBL3911914 0.88 CHRM3 (0.79) CHRM3CHRM2CHRM1
SCHEMBL3913838 0.88 CHRM3 (0.79) CHRM3CHRM2CHRM1
SCHEMBL3911912 0.88 CHRM3 (0.79) CHRM3CHRM2CHRM1
SCHEMBL13717380 0.86 CHRM3 (0.75) CHRM3CHRM2CHRM1
SCHEMBL13749342 0.84 CHRM3 (0.73) CHRM3CHRM2CHRM1
SCHEMBL13717262 0.83 CHRM3 (0.71) CHRM3CHRM2CHRM1
SCHEMBL141495 0.80 CHRM3 (0.67) CHRM3CHRM2CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1677795-B1 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS GLAXO GROUP LTD (GB) 2011-01-05 EP disclosed
US-7579361-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-25 US disclosed
US-7579361-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-25 US disclosed
US-7579361-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-25 US disclosed
US-7576096-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-18 US disclosed
US-7576096-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-18 US disclosed
US-7576096-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2009-08-18 US disclosed
US-20070244150-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-18 US disclosed
US-20070244150-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-18 US disclosed
US-20070244150-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-18 US disclosed
US-20070238752-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-11 US disclosed
US-20070238752-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-11 US disclosed
US-20070238752-A1 Muscarinic Acetylcholine Receptor Antagonists GLAXO GROUP LIMITED 2007-10-11 US disclosed
US-7276521-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2007-10-02 US disclosed
US-7276521-B2 Muscarinic acetylcholine receptor antagonists GLAXO GROUP LIMITED (GB) 2007-10-02 US disclosed
US-20070105895-A1 Muscarinic acetycholine receptor antagonists GLAXO GROUP LIMITED (GB) 2007-05-10 US disclosed
US-20070105895-A1 Muscarinic acetycholine receptor antagonists GLAXO GROUP LIMITED (GB) 2007-05-10 US disclosed
EP-1677795-A4 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS GLAXO GROUP LTD (GB) 2006-12-27 EP disclosed
EP-1677795-A1 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2006-07-12 EP disclosed
WO-2005037280-A1 MUSCARINIC ACETYCHOLINE RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2005-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070238752-A1 Muscarinic Acetylcholine Receptor Antagonists CHRM3, CHRNG, CHRM2 CHRM3 1/4885CHRM2 3/4885CHRM1 19/4885
US-20070244150-A1 Muscarinic Acetylcholine Receptor Antagonists CHRM3, CHRNG, CHRM2 CHRM3 1/4885CHRM2 3/4885CHRM1 19/4885
US-20070105895-A1 Muscarinic acetycholine receptor antagonists CHRM3, CHRNA7, CHRNA2 CHRM3 1/4885CHRM2 7/4885CHRM1 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.