CHRNA2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3358335	0.55	12/20
SCHEMBL4726260	0.47	10/20
SCHEMBL4725595	0.47	9/20
SCHEMBL2495855	0.86	7/20
SCHEMBL4727391	0.86	7/20
SCHEMBL4779724	0.58	7/20
SCHEMBL4779799	0.49	7/20
SCHEMBL2501636	0.69	6/20
SCHEMBL4725985	0.69	6/20
SCHEMBL3930779	0.42	6/20
SCHEMBL2495999	1.00	4/20
SCHEMBL2843467	1.00	4/20
SCHEMBL2497766	0.46	4/20
SCHEMBL3059701	0.43	4/20
SCHEMBL2797723	0.33	4/20
Altinicline (SCHEMBL1155703)	1.00	3/20
Altinicline (SCHEMBL1155706)	1.00	3/20
SCHEMBL2501437	0.80	3/20
SCHEMBL4726141	0.80	3/20
Altinicline (SCHEMBL194945)	0.79	3/20

Clinical trials — most relevant to CHRNA2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING)	PHASE4	COMPLETED
Galantamine for Cognition in People With Schizophrenia	PHASE4	COMPLETED
Postoperative Sugammadex After COVID-19	PHASE4	UNKNOWN
The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease	PHASE4	COMPLETED
Efficacy Study of Galantamine for Cognitive Impairments in Schizophrenia	PHASE4	COMPLETED
Dexmedetomidine Effect on Delirium of Elderly Patients	PHASE4	UNKNOWN
Transcranial Magnetic Stimulation in Patients with Dual Disorders	PHASE3	NOT_YET_RECRUITING
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3	PHASE2	COMPLETED
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3])	PHASE2	COMPLETED
Nicotinic Receptors and Schizophrenia	PHASE1/PHASE2	WITHDRAWN
Nicotinic Receptor Augmentation of SSRI Antidepressants	PHASE2	COMPLETED
Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia	PHASE2	COMPLETED
Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia	PHASE2	COMPLETED
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism	PHASE1/PHASE2	COMPLETED
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition	PHASE2	RECRUITING
Brain Networks and Addiction Susceptibility	PHASE1	COMPLETED
Nicotinic Receptor Genetic Variation and Alcohol Reward	PHASE1	RECRUITING
The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine	PHASE1	WITHDRAWN
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression	nan	COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine	nan	WITHDRAWN
Brain Imaging in Alzheimer's Disease	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia	nan	COMPLETED
Nicotinic Receptor Levels After Stopping Smoking	nan	COMPLETED
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome	nan	COMPLETED
Single Photon Emission Computed Tomography to Study Receptors in Parkinson's Disease	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CHRNA2 binder may also engage these)

Protein	Name	Similarity
Q5IS52	—	1.000	Q5IS52 →
P09480	—	0.998	P09480 →
CHRNA4	Neuronal acetylcholine receptor subunit alpha-4	0.997	landscape →
Q91X60	—	0.997	Q91X60 →
P09483	—	0.995	P09483 →
P09484	—	0.995	P09484 →
CHRNA5	Neuronal acetylcholine receptor subunit alpha	0.995	landscape →
CHRNA6	Neuronal acetylcholine receptor subunit alpha	0.994	landscape →
Q5IS51	—	0.994	Q5IS51 →
Q8R4G9	—	0.992	Q8R4G9 →
P12389	—	0.992	P12389 →
P49581	—	0.992	P49581 →
O70174	—	0.991	O70174 →
Q5IS77	—	0.991	Q5IS77 →
P13908	—	0.990	P13908 →
P49579	—	0.990	P49579 →
P43143	—	0.990	P43143 →
Q07263	—	0.990	Q07263 →
Q8R493	—	0.990	Q8R493 →
Q19AE6	—	0.989	Q19AE6 →
CHRNB4	Neuronal acetylcholine receptor subunit beta-	0.989	landscape →
P12392	—	0.988	P12392 →
P18257	—	0.988	P18257 →
P04757	—	0.988	P04757 →
Q9ERK7	—	0.988	Q9ERK7 →
P12391	—	0.987	P12391 →
Q8SPU7	—	0.987	Q8SPU7 →
Q2MKA5	—	0.986	Q2MKA5 →
Q5IS76	—	0.986	Q5IS76 →
Q27218	—	0.986	Q27218 →