Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | IRS1 | P35568 | 2/20 | 0.48 |
| ▸ | GAB1 | Q13480 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830173 | 0.89 | AKT1 (0.72) | AKT1ALDH1A1KDM4EPOLBPKM | |
| SCHEMBL328517 | 0.88 | AKT1 (0.56) | AKT1ALDH1A1KDM4ELMNAPKM | |
| SCHEMBL12829705 | 0.87 | AKT1 (0.55) | AKT1ALDH1A1KDM4ELMNAPKM | |
| SCHEMBL10108458 | 0.86 | AKT1 (0.53) | AKT1ALDH1A1KDM4ELMNAPKM | |
| SCHEMBL13648772 | 0.84 | AKT1 (0.71) | AKT1ALDH1A1KDM4ELMNAGAB1 | |
| SCHEMBL328512 | 0.84 | AKT1 (0.51) | AKT1ALDH1A1KDM4ELMNAPKM | |
| SCHEMBL282503 | 0.83 | AKT1 (1.00) | AKT1ALDH1A1LMNAPKM | |
| SCHEMBL12829987 | 0.82 | AKT1 (0.55) | AKT1ALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL10108490 | 0.82 | AKT1 (0.69) | AKT1ALDH1A1LMNAPKMIRS1 | |
| SCHEMBL11893077 | 0.78 | AKT1 (0.76) | AKT1ALDH1A1LMNAPKMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |