Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 9/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | IRS1 | P35568 | 2/20 | 0.52 |
| ▸ | GAB1 | Q13480 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10108485 | 0.88 | AKT1 (0.71) | AKT1ALDH1A1KDM4EIRS1GAB1 | |
| SCHEMBL12830173 | 0.87 | AKT1 (0.72) | AKT1ALDH1A1KDM4EPKMHSD17B10 | |
| SCHEMBL12829705 | 0.86 | AKT1 (0.55) | AKT1ALDH1A1KDM4EIRS1GAB1 | |
| SCHEMBL328515 | 0.85 | AKT1 (0.56) | AKT1IRS1GAB1 | |
| SCHEMBL10108458 | 0.84 | AKT1 (0.53) | AKT1ALDH1A1KDM4EIRS1GAB1 | |
| SCHEMBL13648772 | 0.82 | AKT1 (0.71) | AKT1ALDH1A1KDM4EGAB1LMNA | |
| SCHEMBL328512 | 0.82 | AKT1 (0.51) | AKT1ALDH1A1KDM4EIRS1GAB1 | |
| SCHEMBL12829987 | 0.81 | AKT1 (0.55) | AKT1ALDH1A1KDM4EIRS1GAB1 | |
| SCHEMBL11893059 | 0.79 | MEN1 (0.61) | AKT1ALDH1A1PKMHSD17B10MEN1 | |
| SCHEMBL328514 | 0.78 | ALDH1A1 (0.68) | AKT1ALDH1A1PKMHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |