Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011687 | 0.90 | GRM5 (0.46) | GRM5ACHEALDH1A1LMNAHPGD | |
| SCHEMBL1010530 | 0.85 | GRM5 (0.43) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1009118 | 0.85 | GRM5 (0.46) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1010766 | 0.84 | GRM5 (0.46) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1010423 | 0.84 | GRM5 (0.48) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1013119 | 0.84 | GRM5 (0.44) | GRM5ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL1010289 | 0.83 | GRM5 (0.45) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL4081280 | 0.83 | GRM5 (0.44) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1012541 | 0.83 | GRM5 (0.44) | GRM5ALDH1A1LMNAHPGDESR1 | |
| SCHEMBL1011045 | 0.82 | GRM5 (0.43) | GRM5ALDH1A1LMNAHPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | claimed |