Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011172 | 0.91 | GRM5 (0.47) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1010868 | 0.90 | GRM5 (0.41) | GRM5ALDH1A1ESR2POLBESR1 | |
| SCHEMBL12270114 | 0.89 | GRM5 (0.50) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1009983 | 0.86 | GRM5 (0.53) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1011127 | 0.85 | GRM5 (0.48) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1009044 | 0.84 | GRM5 (0.51) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1011128 | 0.84 | TDP1 (0.55) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1010672 | 0.83 | ESR2 (0.54) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL4077715 | 0.83 | GRM5 (0.50) | GRM5TDP1ALDH1A1GAAMAPT | |
| SCHEMBL1010440 | 0.83 | GRM5 (0.50) | GRM5TDP1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | claimed |