Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27571496 | 0.81 | KMT2A (0.46) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL30421216 | 0.81 | KMT2A (0.46) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL4449131 | 0.79 | NPC1 (0.56) | KMT2AMEN1RAB9ANPC1ATM | |
| SCHEMBL30421156 | 0.79 | RAB9A (0.65) | KMT2ARAB9ANPC1HTTATM | |
| SCHEMBL5629538 | 0.79 | RAB9A (0.65) | KMT2ARAB9ANPC1HTTATM | |
| SCHEMBL31076256 | 0.79 | MEN1 (0.60) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL4272878 | 0.79 | MEN1 (0.60) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL13170017 | 0.78 | RAB9A (0.54) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL21847253 | 0.78 | KMT2A (0.46) | KMT2AMEN1RAB9ANPC1S100A4 | |
| SCHEMBL374899 | 0.78 | KMT2A (0.46) | KMT2AMEN1RAB9ANPC1S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409984-A1 | Dimeric IAP Antagonists | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2009094287-A1 | IAP INHIBITORS | TETRALOGIC PHARMACEUTICAL CORPORATION (US) | 2009-07-30 | — | — | WO | disclosed |
| WO-2008014263-A2 | DIMERIC IAP ANTAGONISTS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2008-01-31 | — | — | WO | disclosed |