SCHEMBL10111056

SCHEMBL10111056

c1ccc(-c2nnc(-c3ccc(-n4c5ccccc5c5ccccc54)cc3)n2-c2ccc3c(c2)C(c2ccccc2)(c2ccccc2)c2ccccc2-3)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.38
HPGD P15428 2/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 2/20 0.38
MAPK1 P28482 1/20 0.38
KDM4E B2RXH2 3/20 0.37
ATM Q13315 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
AVPR1A P37288 2/20 0.36
GLA P06280 1/20 0.36
OXTR P30559 2/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
AKT1 P31749 2/20 0.33
OPRD1 P41143 1/20 0.32
AVPR2 P30518 1/20 0.32
HSD11B1 P28845 1/20 0.32
MEN1 O00255 3/20 0.31
KMT2A Q03164 3/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11964529 0.96 KDM4E (0.37) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL10111053 0.94 HPGD (0.40) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL10110993 0.93 KDM4E (0.40) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL13805155 0.93 HPGD (0.34) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL10111063 0.91 KDM4E (0.40) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL10111129 0.90 KDM4E (0.40) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL13805303 0.89 HPGD (0.33) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL13805259 0.89 HPGD (0.35) SMN1; SMN2HPGDALDH1A1LMNAMAPK1
SCHEMBL19167213 0.89 KDM4E (0.39) SMN1; SMN2LMNAKDM4EATML3MBTL1
SCHEMBL13805350 0.89 KDM4E (0.33) SMN1; SMN2HPGDALDH1A1LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160268515-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LAB (JP) 2016-09-15 US disclosed
US-9397299-B2 Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-07-19 US disclosed
US-9397299-B2 Triazole derivative, and light-emitting element, light-emitting device, and electronic device with the use of triazole derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-07-19 US disclosed
US-20140042420-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-13 US disclosed
US-20140042420-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-13 US disclosed
US-20120199818-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-08-09 US disclosed
US-20120199818-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-08-09 US disclosed
US-8178217-B2 4-(4-bromophenyl)-3,5-diphenyl-4H-1,2,4-triazole; high triplet excitation energy; high luminous efficiency, low power consumption SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-05-15 US disclosed
US-8178217-B2 4-(4-bromophenyl)-3,5-diphenyl-4H-1,2,4-triazole; high triplet excitation energy; high luminous efficiency, low power consumption SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2012-05-15 US disclosed
WO-2008143019-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2008-11-27 WO disclosed
US-20080286607-A1 Triazole derivative, and light-emitting device, and electronic device with the use of triazole derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2008-11-20 US disclosed
US-20080286607-A1 Triazole derivative, and light-emitting device, and electronic device with the use of triazole derivative SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2008-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120199818-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE TYR, TH, YEATS4 SMN1; SMN2 4821/4885HPGD 2021/4885ALDH1A1 789/4885
US-20160268515-A1 TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE TYR, TH, YEATS4 SMN1; SMN2 4821/4885HPGD 2021/4885ALDH1A1 789/4885
US-20080286607-A1 Triazole derivative, and light-emitting device, and electronic device with the use of triazole derivative TYR, TH, CYP3A4 SMN1; SMN2 4814/4885HPGD 1695/4885ALDH1A1 562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.