Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011318 | 0.84 | PTGDR2 (0.46) | MAPTSMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL1944730 | 0.83 | MAPT (0.44) | MAPTSMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL1079242 | 0.74 | SLC6A4 (0.41) | SMN1; SMN2HTTLMNASLC6A4SLC6A2 | |
| SCHEMBL1943761 | 0.73 | PTGDR2 (0.46) | MAPTSMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL1009501 | 0.72 | PTGDR2 (0.53) | MAPTSMN1; SMN2HTTNPSR1PTGDR2 | |
| SCHEMBL1066105 | 0.71 | PTGDR2 (0.39) | MAPTSMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL1943429 | 0.70 | PTGDR2 (0.44) | PTGDR2SCN9A | |
| SCHEMBL1944279 | 0.69 | BMP1 (0.47) | MAPTSMN1; SMN2HTTNPSR1ALDH1A1 | |
| SCHEMBL1009651 | 0.69 | KCNQ3 (0.46) | MAPTSMN1; SMN2HTTNPSR1LMNA | |
| SCHEMBL1062726 | 0.69 | PTGDR2 (0.48) | MAPTSMN1; SMN2HTTNPSR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268611-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009145989-A2 | AMINOALKYLPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |