Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CPS1 | P31327 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13203737 | 1.00 | RAB9A (0.61) | RAB9ANPY5RALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL10113981 | 0.83 | RAB9A (0.61) | RAB9AALDH1A1SMN1; SMN2MAPK1ATAD2 | |
| SCHEMBL3576354 | 0.83 | RAB9A (0.85) | RAB9AALDH1A1SMN1; SMN2MAPK1ATAD2 | |
| SCHEMBL13203857 | 0.82 | MEN1 (0.48) | RAB9ANPY5RALDH1A1SMN1; SMN2ATAD2 | |
| SCHEMBL10113322 | 0.82 | MEN1 (0.48) | RAB9ANPY5RALDH1A1SMN1; SMN2ATAD2 | |
| SCHEMBL17089947 | 0.79 | NPC1 (0.42) | RAB9ANPY5RALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL13564740 | 0.79 | NPC1 (0.42) | RAB9ANPY5RALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10133352 | 0.78 | RAB9A (0.47) | RAB9ANPY5RALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL13203777 | 0.78 | RAB9A (0.47) | RAB9ANPY5RALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL29354384 | 0.76 | RAB9A (1.00) | RAB9AALDH1A1SMN1; SMN2ATAD2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7781461-B2 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2010-08-24 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | RAB9A 3651/4885NPY5R 1/4885ALDH1A1 4599/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | RAB9A 3820/4885NPY5R 1/4885ALDH1A1 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.