Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.71 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10113078 | 0.89 | DGAT1 (0.69) | DGAT1KCNQ3KCNQ2TRPV1CYP3A4 | |
| SCHEMBL10113578 | 0.84 | DGAT1 (0.67) | DGAT1TRPV1CYP3A4CYP2C9 | |
| SCHEMBL10006914 | 0.83 | DGAT1 (1.00) | DGAT1TRPV1RAB9AMEN1ALDH1A1 | |
| SCHEMBL5470922 | 0.78 | DGAT1 (0.61) | DGAT1TRPV1RAB9ALMNAHTT | |
| SCHEMBL10007806 | 0.78 | DGAT1 (0.72) | DGAT1TRPV1RAB9ACYP3A4CYP2C9 | |
| SCHEMBL10007264 | 0.78 | DGAT1 (0.71) | DGAT1TRPV1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL10006988 | 0.77 | DGAT1 (1.00) | DGAT1RAB9AMEN1ALDH1A1LMNA | |
| SCHEMBL2145846 | 0.77 | DGAT1 (0.63) | DGAT1KCNQ3KCNQ2TRPV1CYP3A4 | |
| SCHEMBL671338 | 0.77 | DGAT1 (0.61) | DGAT1TRPV1ALDH1A1LMNAHTT | |
| SCHEMBL10007400 | 0.77 | DGAT1 (1.00) | DGAT1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |