Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 17/20 | 0.72 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.59 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10113396 | 0.84 | DGAT1 (0.74) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113679 | 0.82 | DGAT1 (1.00) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113800 | 0.81 | DGAT1 (0.66) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113345 | 0.81 | DGAT1 (0.75) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10112844 | 0.81 | DGAT1 (0.81) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113661 | 0.81 | DGAT1 (0.89) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113366 | 0.81 | DGAT1 (0.87) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113230 | 0.81 | DGAT1 (0.75) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113659 | 0.81 | DGAT1 (1.00) | DGAT1SOAT1CYP3A4SOAT2DGAT2 | |
| SCHEMBL10113332 | 0.80 | DGAT1 (0.86) | DGAT1SOAT1CYP3A4SOAT2DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024179-A1 | SUBSTITUTED AMIDE DERIVATIVES AS DGAT-1 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |