Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10133360 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM4ENPY5RSMN1; SMN2GAA | |
| SCHEMBL13840465 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2GAANPC1 | |
| SCHEMBL12882889 | 0.86 | ALDH1A1 (0.54) | ALDH1A1KDM4ESMN1; SMN2GAANPC1 | |
| SCHEMBL13204259 | 0.85 | NPY5R (0.48) | ALDH1A1KDM4ENPY5RSMN1; SMN2GAA | |
| SCHEMBL10114644 | 0.85 | NPY5R (0.48) | ALDH1A1KDM4ENPY5RSMN1; SMN2GAA | |
| SCHEMBL10134437 | 0.84 | NPY5R (0.44) | ALDH1A1KDM4ENPY5RSMN1; SMN2GAA | |
| SCHEMBL10114398 | 0.84 | NPY5R (0.44) | ALDH1A1KDM4ENPY5RSMN1; SMN2GAA | |
| SCHEMBL10114421 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4ESMN1; SMN2GAANPC1 | |
| SCHEMBL13203715 | 0.83 | KDM4E (0.70) | ALDH1A1KDM4ESMN1; SMN2GAANPC1 | |
| SCHEMBL10113096 | 0.83 | KDM4E (0.70) | ALDH1A1KDM4ESMN1; SMN2GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
| US-20070015762-A1 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015762-A1 | NPY Y5 antagonist | NPY5R, NPY1R, NPY2R | ALDH1A1 4558/4885KDM4E 1668/4885NPY5R 1/4885 |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | ALDH1A1 4599/4885KDM4E 1627/4885NPY5R 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.