Sugi Predict

Sugi Predict / Compounds / SCHEMBL10114550

SCHEMBL10114550

SCHEMBL10114550

CC(C)(C)S(=O)(=O)NC1CCC(C(=O)Nc2ccc(S(=O)(=O)NC3CCCCC3)cc2)CC1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 5/20 0.62
▸ KMT2A Q03164 3/20 0.53
▸ MEN1 O00255 2/20 0.52
▸ ALDH1A1 P00352 1/20 0.52
▸ CYP3A4 P08684 2/20 0.51
▸ CYP2D6 P10635 2/20 0.51
▸ CYP2C9 P11712 2/20 0.51
▸ CYP2C19 P33261 2/20 0.51
▸ GRM4 Q14833 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ NAMPT P43490 1/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ NPY5R Q15761 1/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ RECQL P46063 1/20 0.50
▸ MAPT P10636 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14424790 1.00 LMNA (0.62) LMNAKMT2AMEN1ALDH1A1CYP3A4
SCHEMBL10114575 0.91 LMNA (0.60) LMNAKMT2AMEN1HPGDNAMPT
SCHEMBL14424621 0.91 LMNA (0.60) LMNAKMT2AMEN1HPGDNAMPT
SCHEMBL10114584 0.88 LMNA (0.55) LMNAKMT2AMEN1ALDH1A1NPY5R
SCHEMBL14424258 0.88 LMNA (0.55) LMNAKMT2AMEN1ALDH1A1NPY5R
SCHEMBL10114544 0.87 LMNA (0.56) LMNAKMT2AALDH1A1HPGDGAA
SCHEMBL14424788 0.87 LMNA (0.56) LMNAKMT2AALDH1A1HPGDGAA
SCHEMBL14424354 0.85 SMN1; SMN2 (0.52) LMNAKMT2AMEN1HPGDNAMPT
SCHEMBL10114583 0.85 SMN1; SMN2 (0.52) LMNAKMT2AMEN1HPGDNAMPT
SCHEMBL14424762 0.84 LMNA (0.54) LMNAKMT2AMEN1CYP2C19HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R LMNA 1925/4885KMT2A 2912/4885MEN1 2876/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 2068/4885KMT2A 2768/4885MEN1 2932/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R LMNA 1857/4885KMT2A 2953/4885MEN1 2926/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.