Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | KDM5A | P29375 | 2/20 | 0.42 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloromethane SCHEMBL6087137 | 1.00 | DNM1 (0.55) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| Chloromethane SCHEMBL1011457 | 1.00 | DNM1 (0.55) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| Chloromethane SCHEMBL254040 | 1.00 | DNM1 (0.55) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL409395 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL11804291 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL24187667 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL11864927 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL17599247 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL17599281 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 | |
| SCHEMBL14802918 | 0.94 | DNM1 (0.61) | DNM1TSHRTHRBALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268634-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | Actavis Group PTC EHF (IS) | 2011-01-05 | — | — | EP | claimed |
| WO-2009112954-A2 | PROCESSES FOR THE PREPARATION OF BOSENTAN AND RELATED COMPOUNDS USING NOVEL INTERMEDIATES | ACTAVIS GROUP PTC EHF (IS) | 2009-09-17 | — | — | WO | claimed |