DNM1

Dynamin-1 · Q05193 · DNM1 on Sugi Atlas →

174,399 patent compounds predicted against DNM1, 97,613 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL33718	0.79	14/20
Mecetronium (SCHEMBL60918)	1.00	12/20
Bromide (SCHEMBL60951)	1.00	12/20
Bromide (SCHEMBL25636)	0.94	12/20
Bromide (SCHEMBL44209)	0.94	12/20
SCHEMBL33567	0.65	12/20
SCHEMBL37593	1.00	11/20
SCHEMBL37598	1.00	11/20
SCHEMBL37784	1.00	11/20
Mecetronium (SCHEMBL41715)	1.00	11/20
Didecyldimethylammonium (SCHEMBL29931)	0.94	11/20
SCHEMBL30455	0.94	11/20
SCHEMBL30485	0.94	11/20
Didecyldimethylammonium (SCHEMBL20265)	0.88	11/20
Hydrochloric Acid (SCHEMBL24409)	0.88	11/20
Hydrochloric Acid (SCHEMBL29090)	0.88	11/20
Hydrochloric Acid (SCHEMBL29653)	0.88	11/20
Hydrochloric Acid (SCHEMBL33353)	0.88	11/20
SCHEMBL24179	0.60	11/20
SCHEMBL27777	0.56	11/20

Clinical trials — most relevant to DNM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease	PHASE3	RECRUITING
Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)	PHASE3	COMPLETED
Melpida: Recombinant Adeno-associated Virus (serotype 9) Encoding a Codon Optimized Human AP4M1 Transgene (hAP4M1opt)	PHASE1/PHASE2	RECRUITING
A Clinical Study to Evaluate the Safety of MF1, a New Treatment for Parkinson's Disease-related Disorders (MF1 Study)	PHASE1	RECRUITING
The Safety and Tolerability of CLZ-2002 in Patients With Charcot-Marie Tooth Disease.	PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?	nan	RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Targeting Mitochondrial Fusion and Fission to Prevent Atherosclerosis: Getting the Balance Right	nan	UNKNOWN
Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure	nan	RECRUITING
Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Genetic Variation in CLTCL1 and Whole-body Glucose Control	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Predisposition Genes in Monogenic Diabetes (DIAMONO)	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Identification of New Biomarkers of Insulin Resistance	nan	ACTIVE_NOT_RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DNM1 binder may also engage these)

Protein	Name	Similarity
Q08DF4	—	1.000	Q08DF4 →
DNM2	Dynamin-2	1.000	landscape →
P39053	—	1.000	P39053 →
Q08877	—	1.000	Q08877 →
P39054	—	1.000	P39054 →
P39052	—	1.000	P39052 →
Q9UQ16	—	1.000	Q9UQ16 →
P21575	—	1.000	P21575 →
Q8BZ98	—	1.000	Q8BZ98 →
P27619	—	1.000	P27619 →
A6H7I5	—	1.000	A6H7I5 →
P39055	—	0.997	P39055 →
P20591	—	0.993	P20591 →
P79135	—	0.993	P79135 →
Q5R5G3	—	0.993	Q5R5G3 →
P33237	—	0.992	P33237 →
Q800G5	—	0.992	Q800G5 →
Q28379	—	0.991	Q28379 →
Q9NZN3	—	0.991	Q9NZN3 →
Q86T65	—	0.991	Q86T65 →
Q9QXY6	—	0.991	Q9QXY6 →
Q9H1H9	—	0.991	Q9H1H9 →
O35303	—	0.991	O35303 →
Q94CF0	—	0.991	Q94CF0 →
Q9BDI7	—	0.991	Q9BDI7 →
Q7T2P0	—	0.990	Q7T2P0 →
Q5U752	—	0.990	Q5U752 →
B4NBB0	—	0.990	B4NBB0 →
Q9FNX5	—	0.990	Q9FNX5 →
Q9N0Y3	—	0.990	Q9N0Y3 →