Sugi Predict

Sugi Predict / Compounds / SCHEMBL10116239

SCHEMBL10116239

SCHEMBL10116239

Cc1c(NC(=O)c2ccc(NS(=O)(=O)C(C)C)cc2)ccc(N2C[C@@H](C)O[C@@H](C)C2)c1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.43
▸ LMNA P02545 4/20 0.43
▸ THRB P10828 1/20 0.41
▸ CRHBP P24387 3/20 0.41
▸ CRHR2 Q13324 3/20 0.41
▸ MAPT P10636 2/20 0.40
▸ RXFP1 Q9HBX9 1/20 0.39
▸ KMT2A Q03164 3/20 0.38
▸ ALDH1A1 P00352 3/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ HPGD P15428 1/20 0.37
▸ GSK3B P49841 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ CASP3 P42574 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ SENP6 Q9GZR1 1/20 0.35
▸ SIRT5 Q9NXA8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10133268 1.00 KDM4E (0.43) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL13204919 0.92 KMT2A (0.41) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10134520 0.92 KMT2A (0.41) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10116550 0.92 KMT2A (0.41) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10116488 0.87 KMT2A (0.42) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10116667 0.87 THRB (0.37) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10134540 0.87 THRB (0.37) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10116547 0.86 THRB (0.43) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10116325 0.86 KDM4E (0.43) KDM4ELMNATHRBCRHBPCRHR2
SCHEMBL10134528 0.86 KDM4E (0.43) KDM4ELMNATHRBCRHBPCRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R KDM4E 1668/4885LMNA 1925/4885THRB 414/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R KDM4E 1627/4885LMNA 2068/4885THRB 417/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R KDM4E 1653/4885LMNA 1857/4885THRB 409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.