THRB

Thyroid hormone receptor beta · P10828 · THRB on Sugi Atlas →

958,630 patent compounds predicted against THRB, 590,692 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Liothyronine (SCHEMBL8300)	1.00	14/20
Detrothyronine (SCHEMBL8301)	1.00	14/20
Daunorubicin (SCHEMBL3041)	1.00	10/20
Daunorubicin (SCHEMBL4444)	1.00	10/20
Daunorubicin (SCHEMBL4445)	1.00	10/20
Carubicin (SCHEMBL4201)	0.98	10/20
Idarubicin (SCHEMBL4838)	0.98	10/20
Detorubicin (SCHEMBL8642)	0.81	10/20
Aclarubicin (SCHEMBL4532)	0.67	10/20
Aclarubicin (SCHEMBL4533)	0.67	10/20
Rodorubicin (SCHEMBL8693)	0.54	10/20
Idarubicin (SCHEMBL3750)	1.00	9/20
Carubicin (SCHEMBL9552)	1.00	9/20
Zorubicin (SCHEMBL4023)	0.80	9/20
Zorubicin (SCHEMBL4024)	0.80	9/20
Zorubicin (SCHEMBL8231)	0.79	9/20
Zorubicin (SCHEMBL8232)	0.79	9/20
Amrubicin (SCHEMBL9140)	0.57	9/20
Epirubicin (SCHEMBL3165)	1.00	8/20
Doxorubicin (SCHEMBL3242)	1.00	8/20

Clinical trials — most relevant to THRB by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Life Style Modification and Metformin on Hypothyroidism With Insulin Resistance	PHASE4	UNKNOWN
Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction	PHASE4	COMPLETED
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome)	PHASE2/PHASE3	UNKNOWN
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)	PHASE3	RECRUITING
Antithyroid Drug Treatment of Thyrotoxicosis in Young People	PHASE3	COMPLETED
Thyroid and Glucose and Energy Metabolism	PHASE2	COMPLETED
Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarography	PHASE2	UNKNOWN
Investigating the Effect of Obicetrapib on Lipoprotein Metabolism	PHASE1	ACTIVE_NOT_RECRUITING
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects	nan	RECRUITING
Natural History of Thyroid Function Disorders	nan	RECRUITING
Register for Patients With Thyroid Hormone Resistance.	nan	RECRUITING
Thyroid Function in Liver Cirrhosis: Is it Affected?	nan	COMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism	nan	UNKNOWN
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment	nan	COMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3	nan	COMPLETED
TSH Receptor Mutations Among a Consanguineous Community	nan	COMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism	nan	NOT_YET_RECRUITING
Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism	nan	WITHDRAWN
Effect of Hypothyroidism on Brown Adipose Tissue	nan	COMPLETED
Impact of Thyroid Hormones on Human Glucose and Energy Metabolism	nan	RECRUITING
Aromatase Inhibitor Clinical Trial	nan	UNKNOWN
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation	nan	UNKNOWN
Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism	nan	UNKNOWN
Biosignals by Wearable Devices in Hypothyroidism	nan	COMPLETED
Polymorphisms in the Vitamin D System and Health	nan	COMPLETED
Short Term Outcome of Metabolic Associated Fatty Liver Disease (MAFLD) in Patients Undergoing Bariatric Surgery	nan	UNKNOWN
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine	nan	RECRUITING
Comparison of Thyroid Volumes in Patients With and Without Endometrioma	nan	COMPLETED
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures	nan	COMPLETED
Effect of Exercise on Irisin Levels of Hypothyroid Rats	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a THRB binder may also engage these)

Protein	Name	Similarity
Q9W785	—	1.000	Q9W785 →
P37242	—	1.000	P37242 →
Q28570	—	1.000	Q28570 →
Q91241	—	1.000	Q91241 →
P18113	—	1.000	P18113 →
O57606	—	1.000	O57606 →
Q9W6N4	—	1.000	Q9W6N4 →
P18119	—	1.000	P18119 →
O42450	—	1.000	O42450 →
Q28037	—	1.000	Q28037 →
P13053	—	1.000	P13053 →
P48281	—	1.000	P48281 →
F1QLY4	—	1.000	F1QLY4 →
Q91242	—	1.000	Q91242 →
Q28571	—	1.000	Q28571 →
A3RGC1	—	0.999	A3RGC1 →
Q91279	—	0.999	Q91279 →
VDR	Vitamin D3 receptor	0.999	landscape →
Q98867	—	0.999	Q98867 →
P49701	—	0.999	P49701 →
P04625	—	0.999	P04625 →
P18115	—	0.998	P18115 →
P45446	—	0.998	P45446 →
Q90382	—	0.998	Q90382 →
Q9PTN2	—	0.997	Q9PTN2 →
Q95MH5	—	0.997	Q95MH5 →
P15204	—	0.997	P15204 →
P49882	—	0.997	P49882 →
P18117	—	0.997	P18117 →
O42295	—	0.997	O42295 →