SCHEMBL10116474

SCHEMBL10116474

CCN(Cc1ccc(-c2ccc(CN(C)c3ccc(C)cc3)cc2)cc1)c1ccc(C)cc1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.50
CNR2 P34972 16/20 0.49
CNR1 P21554 12/20 0.48
TSHR P16473 1/20 0.47
HRH3 Q9Y5N1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12679039 0.95 CYP2C19 (0.46) CYP2C19CNR2CNR1TSHR
SCHEMBL12679019 0.95 CYP2C19 (0.55) CYP2C19CNR2CNR1TSHR
SCHEMBL4400864 0.92 CYP2C19 (0.58) CYP2C19CNR2CNR1TSHRHRH3
SCHEMBL12144199 0.92 CNR2 (0.43) CYP2C19CNR2CNR1TSHR
SCHEMBL15087674 0.90 CNR2 (0.58) CYP2C19CNR2CNR1
SCHEMBL12679026 0.88 HRH3 (0.52) CYP2C19CNR2TSHRHRH3
SCHEMBL13778830 0.87 CYP2C19 (0.53) CYP2C19CNR2CNR1TSHRHRH3
SCHEMBL4402212 0.86 CYP2C19 (0.64) CYP2C19CNR2CNR1TSHR
SCHEMBL22340785 0.86 CYP2C19 (0.64) CYP2C19CNR2CNR1TSHR
SCHEMBL10117093 0.85 TSHR (0.68) CYP2C19CNR2CNR1TSHRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120321348-A1 IMAGE BEARING DRUM, IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, AND PROCESS CARTRIDGE RICOH COMPANY, LTD. (JP) 2012-12-20 US disclosed
US-8273513-B2 Image forming apparatus, process cartridge, and image bearing member RICOH COMPANY, LIMITED (JP) 2012-09-25 US disclosed
EP-2146251-B1 Electrophotographic photoconductor, image forming apparatus using the same, and process cartridge RICOH CO LTD (JP) 2012-02-08 EP disclosed
US-20100330475-A1 IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE BEARING MEMBER RICOH COMPANY LIMITED (JP) 2010-12-30 US disclosed