Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 16/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011760 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL2543044 | 0.86 | CYP3A4 (0.55) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1011759 | 0.81 | CYP3A4 (0.52) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1009417 | 0.76 | CYP3A4 (0.48) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1009415 | 0.76 | CYP3A4 (0.48) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1012025 | 0.76 | FAAH (0.51) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1011197 | 0.75 | FAAH (0.44) | CYP3A4CYP2D6FAAHCYP2C9 | |
| SCHEMBL1009793 | 0.73 | CYP3A4 (0.76) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1010705 | 0.72 | FAAH (0.50) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1010255 | 0.71 | FAAH (0.43) | CYP3A4CYP2D6FAAHGABRA1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-B1 | BIARYL ETHER UREA COMPOUNDS | PFIZER PROD INC (US) | 2011-01-05 | — | — | EP | disclosed |