Sugi Predict

Sugi Predict / Targets / FAAH

FAAH

Fatty-acid amide hydrolase 1 · O00519 · FAAH on Sugi Atlas →

442,226 patent compounds predicted against FAAH, 240,450 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL24161 SCHEMBL24161 0.65 20/20
SCHEMBL30332 SCHEMBL30332 0.64 20/20
SCHEMBL31088 SCHEMBL31088 0.62 20/20
SCHEMBL30252 SCHEMBL30252 0.61 20/20
SCHEMBL24632 SCHEMBL24632 0.61 20/20
SCHEMBL31095 SCHEMBL31095 0.60 20/20
SCHEMBL30193 SCHEMBL30193 0.60 20/20
SCHEMBL30194 SCHEMBL30194 0.60 20/20
SCHEMBL24023 SCHEMBL24023 0.59 20/20
SCHEMBL30058 SCHEMBL30058 0.58 20/20
SCHEMBL30050 SCHEMBL30050 0.51 20/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL29406) 0.50 20/20
SCHEMBL29668 SCHEMBL29668 0.50 20/20
SCHEMBL31040 SCHEMBL31040 0.50 19/20
Phenyramidol Phenyramidol (SCHEMBL21963) 0.50 10/20
SCHEMBL42734 SCHEMBL42734 0.75 8/20
SCHEMBL18713 SCHEMBL18713 0.74 8/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL28875) 0.53 8/20
SCHEMBL23352 SCHEMBL23352 0.52 8/20
SCHEMBL19975 SCHEMBL19975 0.77 6/20

Clinical trials — most relevant to FAAH by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Effects of Nabilone on Endocannabinoid Metabolism PHASE4COMPLETED
Treatment Strategies in CHS PHASE4COMPLETED
Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain PHASE4COMPLETED
Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS) PHASE2COMPLETED
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity PHASE2RECRUITING
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal PHASE2COMPLETED
Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD) PHASE2COMPLETED
Analgesic Efficacy of Pre-Operative Dose of Palmitoylethanolamide in Patients Undergoing Total Knee Arthroplasty PHASE1/PHASE2NOT_YET_RECRUITING
Safety and Efficacy Study of PEA and Polydatin on Intestinal Inflammation and Visceral Hyperalgesia in IBS Patients PHASE2UNKNOWN
Palmitoylethanolamide for Chronic Inflammatory Pain Conditions PHASE2RECRUITING
Safety, Tolerability, and Pharmacokinetics of Multiple Doses of Oral EC5026 in Healthy Subjects PHASE1COMPLETED
Safety, Tolerability, and Pharmacokinetics of Oral EC5026 in Healthy Subjects PHASE1COMPLETED
Safety, Tolerability, Pharmacokinetics and Food Effects of Oral EC5026 in Healthy Subjects PHASE1COMPLETED
First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes PHASE1COMPLETED
Topical Cannabidiol Cream and Post-exercise Recovery EARLY_PHASE1WITHDRAWN
Gene Expression of Endocannabinoid System in Episodic and Chronic Migraine Patients nanCOMPLETED
Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin nanENROLLING_BY_INVITATION
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers nanCOMPLETED
Biochemical Profiling of Migraine Patients nanRECRUITING
Psychological and Biological Markers of Refractory Migraine nanUNKNOWN
Effect of OMM on Anandamide Levels in Saliva nanCOMPLETED
Dietary Essential Fatty Acid Regulation of Omega-3 HUFA Metabolism; Satiety and Body Composition nanCOMPLETED
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments nanRECRUITING
Prostaglandin and Cannabinoid Receptors in EoE nanCOMPLETED
Gastric Bypass and Peripheral Activity of the Endocannabinoid System nanCOMPLETED
Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving CIPN in Patients With Colon or Breast Cancer After End of Adj. Therapy nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence nanCOMPLETED
Modulatory Effects of Active Drugs on the Endocannabinoid System on Spontaneous and Induced Contractility of the Colon nanCOMPLETED
Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALS nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FAAH binder may also engage these)

ProteinNameSimilarity
O08914 — 1.000 O08914 →
Q9TUI8 — 0.999 Q9TUI8 →
P97612 — 0.998 P97612 →
Q90578 — 0.988 Q90578 →
Q6DH69 — 0.987 Q6DH69 →
Q05AM4 — 0.983 Q05AM4 →
FAAH2 Fatty-acid amide hydrolase 2 0.967 landscape →
Q865R1 — 0.966 Q865R1 →
E2QUI9 — 0.963 E2QUI9 →
Q5NVK5 — 0.962 Q5NVK5 →
O60294 — 0.962 O60294 →
P83006 — 0.962 P83006 →
Q99487 — 0.961 Q99487 →
P79106 — 0.961 P79106 →
Q5EA80 — 0.961 Q5EA80 →
PAOX Peroxisomal N(1)-acetyl-spermine/spermidine oxidase 0.961 landscape →
P47823 — 0.960 P47823 →
Q921Q3 — 0.960 Q921Q3 →
Q86TX2 — 0.960 Q86TX2 →
Q8VDG7 — 0.960 Q8VDG7 →
A5A779 — 0.960 A5A779 →
Q9CZ42 — 0.960 Q9CZ42 →
P12785 — 0.960 P12785 →
Q9D0Z3 — 0.960 Q9D0Z3 →
E1BNQ4 — 0.960 E1BNQ4 →
Q6NUM9 — 0.959 Q6NUM9 →
LPCAT1 Lysophosphatidylcholine acyltransferase 1 0.959 landscape →
Q8IVS8 — 0.959 Q8IVS8 →
Q5I0L3 — 0.959 Q5I0L3 →
ALG1 Chitobiosyldiphosphodolichol beta-mannosyltransferase 0.958 landscape →