Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | RHOC | P08134 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845297 | 0.91 | RHOC (0.48) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL873223 | 0.89 | RHOC (0.43) | RHOCRHOATRPV1ROCK2SCN3A | |
| SCHEMBL845234 | 0.85 | RHOC (0.43) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL845461 | 0.84 | PREP (0.44) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL844960 | 0.84 | DPP4 (0.43) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL872436 | 0.84 | DPP4 (0.43) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL10119636 | 0.83 | CYP2C9 (0.38) | TRPV1ROCK2SCN3ASCN9AJAK2 | |
| SCHEMBL10119551 | 0.83 | DHODH (0.40) | TRPV1ROCK2SCN3ASCN9AJAK2 | |
| SCHEMBL845231 | 0.82 | HCRTR1 (0.43) | RHOCRHOATRPV1ROCK2VNN1 | |
| SCHEMBL10222762 | 0.82 | DHODH (0.45) | ITGB3ITGAVITGA2BROCK2SCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |