Sugi Predict

Sugi Predict / Targets / RHOC

RHOC

Rho-related GTP-binding protein RhoC · P08134 · RHOC on Sugi Atlas →

8,511 patent compounds predicted against RHOC, 4,954 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1534454 SCHEMBL1534454 1.00 17/20
SCHEMBL1534236 SCHEMBL1534236 1.00 13/20
SCHEMBL1534247 SCHEMBL1534247 1.00 13/20
SCHEMBL1534304 SCHEMBL1534304 0.64 13/20
SCHEMBL1534265 SCHEMBL1534265 1.00 12/20
SCHEMBL1534393 SCHEMBL1534393 1.00 12/20
SCHEMBL1534267 SCHEMBL1534267 1.00 10/20
SCHEMBL1534352 SCHEMBL1534352 1.00 10/20
SCHEMBL1534289 SCHEMBL1534289 0.67 10/20
SCHEMBL1534246 SCHEMBL1534246 1.00 9/20
SCHEMBL1534174 SCHEMBL1534174 0.72 9/20
SCHEMBL1420128 SCHEMBL1420128 0.52 9/20
SCHEMBL1534160 SCHEMBL1534160 0.67 8/20
SCHEMBL1534239 SCHEMBL1534239 0.54 8/20
SCHEMBL1534252 SCHEMBL1534252 1.00 7/20
SCHEMBL1534288 SCHEMBL1534288 1.00 7/20
SCHEMBL1534299 SCHEMBL1534299 1.00 7/20
SCHEMBL1534394 SCHEMBL1534394 1.00 7/20
SCHEMBL1534398 SCHEMBL1534398 0.71 7/20
SCHEMBL1534313 SCHEMBL1534313 0.71 7/20

Clinical trials — most relevant to RHOC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Myocilin Genetic Variants on Intraocular Pressure and Pressure Variation in Sitting and Supine Positions PHASE4COMPLETED
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Simvastatin in Secondary Progressive Multiple Sclerosis PHASE2COMPLETED
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136) PHASE2ACTIVE_NOT_RECRUITING
Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula PHASE2COMPLETED
Phase II Dasatinib Study in Advanced Breast Cancer PHASE2COMPLETED
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS PHASE1/PHASE2RECRUITING
A Clinical Study on Fasudil Hydrochloride for Treatment of Gene-Specific Ovarian Cancer PHASE2RECRUITING
Effect of Simvastatin on CF Airway Inflammation PHASE1COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
Safety and Tolerability Study of Gene Editing Drug ZVS203e in Participants With Retinitis Pigmentosa EARLY_PHASE1UNKNOWN
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Glucagon Like Peptide-1 in Remote Ischemic Conditioning nanCOMPLETED
Immune Cell Response to Stimuli nanRECRUITING
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke nanCOMPLETED
Shanghai High Myopia Study nanRECRUITING
Rostock International Parkinson's Disease Study (ROPAD) nanCOMPLETED
IVM for Patients With Low Ovarian Response. Does it Improve IVFoutcomes and Does it Improve the Following IVF Cycle? nanUNKNOWN
Network Of Clinical Research Studies On Craniosynostosis, Skull Malformations With Premature Fusion Of Skull Bones nanACTIVE_NOT_RECRUITING
Studying the Role of Circulating Tumor Cell Clusters in Patients With High-risk Early Breast Cancer, Study GALIA nanRECRUITING
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer nanUNKNOWN
Multi-Dimensional Genomic Dissection of Ring Chromosome 14 Syndrome nanACTIVE_NOT_RECRUITING
Effect of Esterogen Receptor Modulator on Gene in Bipolar Diseas nanNOT_YET_RECRUITING
Effects of Remote Cardiac Ischemic Preconditioning nanUNKNOWN
Blood-based Biomarkers for the Prognosis of Sports Related Concussion nanCOMPLETED
Genetic Testing in Primary Congenital Glaucoma Patients nanUNKNOWN
Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F nanACTIVE_NOT_RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a RHOC binder may also engage these)

ProteinNameSimilarity
Q1RMJ6 — 1.000 Q1RMJ6 →
Q5RCK9 — 1.000 Q5RCK9 →
Q62159 — 1.000 Q62159 →
Q7T2E8 — 1.000 Q7T2E8 →
Q6DHE8 — 1.000 Q6DHE8 →
P24406 — 1.000 P24406 →
P61589 — 1.000 P61589 →
Q6NUX8 — 1.000 Q6NUX8 →
Q9PSX7 — 1.000 Q9PSX7 →
P61585 — 0.998 P61585 →
RHOA Transforming protein RhoA 0.998 landscape →
P62747 — 0.996 P62747 →
Q22038 — 0.996 Q22038 →
Q3ZBW5 — 0.995 Q3ZBW5 →
Q6DHM9 — 0.995 Q6DHM9 →
P01122 — 0.995 P01122 →
Q9QUI0 — 0.994 Q9QUI0 →
Q9C3Y4 — 0.993 Q9C3Y4 →
P48148 — 0.993 P48148 →
P62746 — 0.992 P62746 →
Q5REY6 — 0.992 Q5REY6 →
P62745 — 0.991 P62745 →
Q03206 — 0.988 Q03206 →
P22122 — 0.987 P22122 →
Q09914 — 0.980 Q09914 →
RAC2 Ras-related C3 botulinum toxin substrate 2 0.980 landscape →
Q9TU25 — 0.979 Q9TU25 →
P62999 — 0.979 P62999 →
RAC1 Ras-related C3 botulinum toxin substrate 1 0.979 landscape →
CDC42 Cell division control protein 42 homolog 0.979 landscape →