Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015120 | 0.86 | BRAF (0.76) | BRAFRAF1 | |
| SCHEMBL1780730 | 0.85 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL17046528 | 0.84 | BRAF (0.81) | BRAFRAF1 | |
| SCHEMBL1012324 | 0.83 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL18660163 | 0.82 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL1012223 | 0.81 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1012725 | 0.78 | BRAF (0.76) | BRAFRAF1 | |
| SCHEMBL1012919 | 0.78 | BRAF (0.76) | BRAFRAF1 | |
| SCHEMBL13680221 | 0.78 | BRAF (0.87) | BRAFRAF1 | |
| SCHEMBL18676498 | 0.78 | BRAF (0.87) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011529021-A | — | — | 2011-12-01 | — | — | JP | claimed |
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | claimed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | claimed |
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |