Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890536 | 0.84 | PIK3CD (0.59) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL10120340 | 0.77 | PIK3CD (0.36) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL3098056 | 0.77 | KDM4E (0.45) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL10119948 | 0.74 | PIK3CD (0.80) | PIK3CD | |
| SCHEMBL890545 | 0.70 | KDM4E (0.44) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL890481 | 0.69 | PIK3CD (0.54) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL3962921 | 0.68 | KDM4E (0.47) | HSP90AA1HSP90AB1ALDH1A1KDM4EGLA | |
| SCHEMBL17718397 | 0.68 | USP7 (0.47) | PIK3CDHSP90AA1HSP90AB1ALDH1A1KDM4E | |
| SCHEMBL16340515 | 0.68 | PIK3CD (0.48) | PIK3CDALDH1A1KDM4EGLAGAA | |
| SCHEMBL3962874 | 0.68 | ENPP2 (0.52) | PIK3CDALDH1A1KDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CD 24/4885HSP90AA1 1973/4885HSP90AB1 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.