ENPP2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL46295	1.00	20/20
SCHEMBL46301	1.00	20/20
SCHEMBL46345	1.00	20/20
SCHEMBL46560	1.00	20/20
SCHEMBL46565	1.00	20/20
SCHEMBL46598	1.00	20/20
SCHEMBL46617	1.00	20/20
SCHEMBL46628	1.00	20/20
SCHEMBL46826	1.00	20/20
SCHEMBL46630	0.92	20/20
SCHEMBL46313	0.85	20/20
SCHEMBL46603	0.85	20/20
SCHEMBL46578	0.84	20/20
SCHEMBL46304	0.83	20/20
SCHEMBL46612	0.82	20/20
SCHEMBL46811	0.82	20/20
SCHEMBL46571	0.81	20/20
SCHEMBL46824	0.80	20/20
SCHEMBL47766	0.80	20/20
SCHEMBL46602	0.79	20/20

Clinical trials — most relevant to ENPP2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis	PHASE3	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
A Study to Assess the Safety and Efficacy of 3 Doses of ALX1-11 (50, 75, and 100µg) in the Treatment of Postmenopausal Osteoporosis	PHASE2	COMPLETED
Anti-CD38 Antibody Treating APS With Thrombocytopenia	PHASE2	RECRUITING
Assessment of Coronary Plaque Composition	PHASE1	COMPLETED
A Study of ES002023 (Anti-CD39 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors	PHASE1	COMPLETED
The dıagnostıc Value of Serum autotaxın Level ın Colorectal Cancer	nan	COMPLETED
Autotaxin as Abiomarker in Systemic Lupus Erythematosus Patients	nan	UNKNOWN
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2)	nan	COMPLETED
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Lysophosphatidic Acid / Autotaxin Axis in Rheumatoid Lung Disease	nan	UNKNOWN
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
An Outcome Analysis of Primary Membranous Nephropathy	nan	RECRUITING
Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis)	nan	COMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Understanding the Spectrum of ENPP1 Deficiency and Acute ABCC6 Deficiency	nan	COMPLETED
Effect of B-cell Depleting Therapies on PLA2R-specific B Cells in Patients With Membranous Nephropathy	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma	nan	SUSPENDED
Genetic Architecture of Chronic Inflammatory Demyelinating Polyradiculoneuropathy	nan	UNKNOWN
Comparison of the Proteome in ICU Patients in Search for TRALI Biomarkers: A Case-control Study Using Both Retrospective and Prospective Samples	nan	NOT_YET_RECRUITING
Multi-Analyte, Genetic, and Thrombogenic Markers of Atherosclerosis	nan	UNKNOWN
Exome Sequencing for Atypical Femoral Fractures	nan	COMPLETED
Identification of Autoantigens in EGPA and Severe Eosinophilic Asthma	nan	COMPLETED
Physiopathology of Pulmonary Arterial Hypertension: Mechanistic Studies	nan	UNKNOWN
Immune Biomarkers Related to Bone Pathology in Patients With Type 1 Gaucher Disease	nan	UNKNOWN
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ENPP2 binder may also engage these)

Protein	Name	Similarity
Q9R1E6	—	1.000	Q9R1E6 →
Q64610	—	1.000	Q64610 →
A1A4K5	—	0.998	A1A4K5 →
ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	0.988	landscape →
ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase family member 3	0.981	landscape →
Q6DYE8	—	0.981	Q6DYE8 →
Q5R5M5	—	0.980	Q5R5M5 →
P15396	—	0.979	P15396 →
W8E7D1	—	0.976	W8E7D1 →
P97675	—	0.975	P97675 →
P0DQQ4	—	0.975	P0DQQ4 →
J3SBP3	—	0.972	J3SBP3 →
A8MWY0	—	0.972	A8MWY0 →
J3SEZ3	—	0.970	J3SEZ3 →
P06802	—	0.969	P06802 →
Q3UZV7	—	0.969	Q3UZV7 →
Q924C3	—	0.969	Q924C3 →
A0A2D0TC04	—	0.968	A0A2D0TC04 →
A7E2Z9	—	0.967	A7E2Z9 →
CSGALNACT1	Chondroitin sulfate N-acetylgalactosaminyltransferase 1	0.967	landscape →
Q66PG2	—	0.966	Q66PG2 →
P79282	—	0.966	P79282 →
Q8R4K8	—	0.965	Q8R4K8 →
Q9EPS3	—	0.965	Q9EPS3 →
F1QR43	—	0.964	F1QR43 →
Q6BEA0	—	0.964	Q6BEA0 →
O94923	—	0.964	O94923 →
Q4R854	—	0.964	Q4R854 →
Q8N6G5	—	0.964	Q8N6G5 →
Q8BJQ9	—	0.964	Q8BJQ9 →