SCHEMBL10120342

SCHEMBL10120342

COc1ccc(-c2nc(N)sc2-c2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.73
MAPT P10636 6/20 0.73
CYP1A2 P05177 2/20 0.73
CYP2D6 P10635 2/20 0.73
CYP2C19 P33261 2/20 0.73
KDM4E B2RXH2 5/20 0.69
CYP3A4 P08684 1/20 0.69
GAA P10253 1/20 0.69
CYP2C9 P11712 1/20 0.69
MAPK1 P28482 3/20 0.61
LMNA P02545 3/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
NPSR1 Q6W5P4 3/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
XBP1 P17861 1/20 0.59
PKM P14618 2/20 0.58
HTT P42858 1/20 0.58
POLB P06746 1/20 0.57
TDP1 Q9NUW8 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16669665 0.98 ALDH1A1 (0.75) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL8067414 0.92 MAPT (0.69) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
Hydrochloric Acid SCHEMBL9548025 0.91 KDM4E (0.67) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL6338072 0.86 MAPT (0.75) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL234287 0.85 ALDH1A1 (1.00) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL10120487 0.85 KDM4E (0.59) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL6284661 0.85 KDM4E (0.59) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL7050538 0.85 MAPT (0.59) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL6282476 0.83 CYP19A1 (0.55) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19
SCHEMBL8067428 0.83 MAPT (0.87) ALDH1A1MAPTCYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012006068-A2 COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-01-12 WO disclosed